Acute Respiratory Failure With Hypoxia Clinical Trial
— IRAvistaOfficial title:
High-flow Oxygen Therapy Versus Non-invasive Ventilation: a Randomised Physiological Cross-over Study of Alveolar Recruitment in Acute Respiratory Failure
Verified date | December 2020 |
Source | University Hospital, Rouen |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF. Although NIV provided better oxygenation than HFNC, the effect on lung volumes could explain the potentially deleterious effect of NIV in hypoxemic ARF, reinforcing the recently developed concept of patient self-inflicted lung injury.
Status | Completed |
Enrollment | 16 |
Est. completion date | February 19, 2018 |
Est. primary completion date | February 13, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult patients referred in ICU - with hypoxemic acute respiratory failure due to a community acquired pneumonia confirmed by chest X ray, - with PaO2 < 60mmHg in ambient air, without hypercapnia (PaCO2 < 45 mmHg), - requiring more than 6L/min of O2 on admission with high concentration FM, and justifying HFNC or NIV for the attending ICU physician Exclusion Criteria: - cardiogenic pulmonary oedema, - moderate to severe underlying respiratory disease including COPD (chronic obstructive pulmonary disease) - contraindication to or failure of previous NIV or HFNC with the need for immediate invasive ventilation - pregnant or breast-feeding women - carrier of an implantable defibrillator or pacemaker - body mass index (BMI)>50 kg/m2 - with cutaneous lesion next to the positioning zone of the Pulmovista® (Dräger, Lübeck, Germany) belt |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Rouen |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | global EELI | measurement of global end respiratory lung impedance with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic | |
Secondary | ROI EELI | measurement of regional of interest (ROI) end respiratory lung impedance with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic | |
Secondary | global TV | measurement of global tidal variation (TV) with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic | |
Secondary | ROI TV | measurement of regional tidal variation with non invasive ventilation vs with high flow nasal canulae oxygen therapy, standard unit | after 5 minutes of stable breathing with the oxygenation technic |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04681040 -
Risk Stratification of COVID-19 Using Urine Biomarkers
|
||
Active, not recruiting |
NCT04079829 -
Postoperative Respiratory Abnormalities
|
||
Completed |
NCT03021824 -
Severe ARDS: Generating Evidence
|
||
Active, not recruiting |
NCT02654327 -
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
|
Phase 3 | |
Completed |
NCT04693403 -
Adult Respiratory Failure Intervention Study Africa
|
N/A | |
Recruiting |
NCT04368975 -
ARDS Caused by COVID-19
|
||
Recruiting |
NCT02050217 -
NAVA Helmet in Pediatric Respiratory Failure
|
Phase 3 | |
Recruiting |
NCT04912960 -
PEEP in Patients With Acute Respiratory Failure
|
||
Recruiting |
NCT03311087 -
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
|
||
Recruiting |
NCT03467854 -
PK of Piperacillin/Tazobactam in Adults Undergoing ECMO
|
||
Completed |
NCT02167542 -
Positive Pressure During Bronchoscopy
|
N/A | |
Completed |
NCT03326830 -
Prehospital High-Flow Nasal Oxygen Therapy
|
N/A | |
Terminated |
NCT01937884 -
Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
|
Phase 2 |