Other Clinical Trial - Folfox+Irinotecan+Chemort In Esophageal Cancer

Status Recruiting

Clinical Trial Summary

In this research study, is studying how Liposomal Irinotecan in combination with the standard of care interventions FOLFOX, carboplatin paclitaxel, and radiation therapy affect gastroesophageal junction or esophagogastric cancer This research study involves the following study intervention: - Liposomal irinotecan

Clinical Trial Description

The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. This research study involves the following standard of care interventions: - FOLFOX (leucovorin calcium, 5-Fluorouracil, and oxaliplatin) - Carboplatin - Paclitaxel - Radiation therapy This research study involves the following study intervention: - Liposomal irinotecan It is expected that about 40 people will take part in this research study. This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. "Investigational" means that the intervention is being studied. The U.S. Food and Drug Administration (FDA) has not approved liposomal irinotecan for your specific disease but it has been approved for other uses. The FDA has approved FOLFOX, carboplatin, and paclitaxel as treatment options for this disease. ;

Study Design

Related Conditions & MeSH terms

Adenocarcinoma
Esophageal Neoplasms
Esophagogastric Cancer
Gastroesophageal Junction Adenocarcinoma

Clinical Trial Details

NCT number	NCT04656041
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Theodore S Hong, MD
Phone	(617) 726-6050
Email	tshong1@mgh.harvard.edu
Status	Recruiting
Phase	Phase 2
Start date	June 29, 2021
Completion date	December 2027

View Details

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