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Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery

Coronary Artery Occlusive Disease Clinical Trial

Official title:
Effect of Intraoperative Iloprost Inhalant on Hemodynamic Stability in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery: a Randomized, Blinded Clinical Trial

Clinical Trial Summary

Considering that the cause of hemodynamic instability during OPCAB is closely related to right ventricular dysfunction with pulmonary artery hypertension, the use of inhaled iloprost (a selective pulmonary vasodilator) in patients undergoing OPCAB maybe beneficial for hemodynamic management. Previous research has showed that inhaled iloprost reduce pulmonary arterial pressure and pulmonary vascular resistance. Therefore, by administering inhaled iloprost before the graft anastomosis might improve cardiac output, mixed venous blood oxygen saturation, and pulmonary oxygenation during the surgery especially during the graft anastomosis. The objective of our study is to evaluate the effect of inhaled Iloprost on hemodynamic stability in patients undergoing off-pump coronary artery bypass graft surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Coronary Artery Occlusive Disease
Clinical Trial Details
NCT number NCT04598191
Study type Interventional
Source Yonsei University
Contact Jae Kwang Shim
Phone 82-2-2228-8516
Email ANESHIM@yuhs.ac
Status Recruiting
Phase N/A
Start date November 4, 2020
Completion date December 2022
View Details
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