Neuromuscular Control in Individuals Following ACL-Reconstruction

Anterior Cruciate Ligament Injuries Clinical Trial

Official title:

The Use of Visuomotor Therapy to Modulate Corticospinal Excitability in Patients Following ACL-Reconstruction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04495075
• Other study ID #: 20441
• Status: Completed
• Phase: N/A
• Start date: March 1, 2019
• Est. completion date: March 1, 2020

Study information

• Verified date: July 2020
• Source: University of Virginia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the neurophysiological contributors to muscle function following ACL Reconstruction and the influence of motor control biofeedback exercise on measures of muscle function. The research team hypothesizes that the application of motor biofeedback will increase cortical excitability of the quadriceps compared to the passive movement of the knee.

This is a single session cross-over intervention study with a 1-week washout period between treatment arms.

Description:

1. Pre-treatment neuromuscular assessment Cortical Active Motor Threshed We will measure motor evoked potentials with the use of a Transcranial magnetic stimulator (MagStim model 200, Magstim Co., Ltd., Wales, UK). The MagStim has FDA 510K Clearance for stimulation of peripheral nerves.

• The participant will be asked to sit in the dynamometer (Biodex, System 3) in knee extension at 90 degrees of knee flexion.

• EMG electrodes will be placed on the distal quadriceps

o Local shaving, debridement, and cleaning will be done prior if necessary

• A non-latex swim cap will be placed on the participants head for investigator's measurements

• Briefly, a magnetic field with a maximum value of 2.2 Tesla will be introduced to the scalp at a location in the pre-motor cortex that corresponds to the quadriceps. Single pulse stimulations will be delivered with no less than 10 seconds between stimulations (maximum = 0.1 Hz).

• When the magnetic field is received at the premotor cortex at the appropriate area, a motor signal is sent to the quadriceps. We will record this signal with surface EMG electrodes that are on the quadriceps.

• The participant will be asked to extend their leg to match a force equivalent to 5% MVIC. Feedback will be provided to the participant to provide such force.

• Stimulation of the TMS will happen once every ten seconds until the Active Motor Threshold was found by the investigator.

• The motor evoked potential measured by the quadriceps will be recorded at 80%, 90%, 100%, 110%, 120%, 130%, 140%, and 150% of the patients Active motor threshold.

2. Patient randomization

• The patient is then randomized to 1 of 2 treatment arms. 1) Visuomotor Therapy or 2) Passive Motion

3. Perform Randomized Treatment Visuomotor Therapy

• The participant will sit in the Biodex chair with the tested limb secured in the dynamometer

• The participant will receive live real-time biofeedback of their knee force output (no more than 30% of maximum force)

• The participant will aim to match their force output to a target threshold presented on the screen.

• The participant will complete 10 60-second trials of this exercise with a 30 second rest between each trial.

OR

Passive Motion

• The participant will sit in the Biodex chair with the tested limb secured in the dynamometer

• The dynamometer will passively move the patients lower limb between 80 to 120 degrees of knee flexion

• The participant will be asked to relax for the duration of testing - The participant will complete 10 60-second trials of this exercise with a 30 second rest between each trial.

4. Reassess Neuromuscular outcome (Step 1)

5. 1-week washout period

6. Repeat Steps 1 through 4 but the patient receives the cross-over arm intervention

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 1, 2020
• Est. primary completion date: March 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• • Ages 18-45

• At the time point of return to play progression following ACL Reconstruction

• Physically active individuals based on current ACSM guidelines of 30 minutes of moderate-intensity daily physical activity three days a week)

Exclusion Criteria:

• Subjects who are known to be pregnant (self-reported)

• Subjects diagnosed with malignancy

• Subjects with serious infection near the lower limb

• Subjects with known muscular abnormalities

• History of cardiopulmonary disorder

• Subjects with a previous history of stroke

• History of neurological or psychiatric disorders including poorly controlled migraine headaches, seizure disorder, history or immediate family history of seizures and/or epilepsy

• Subjects with any type of neuropathy (numbness and tingling)

• Subjects with a clinical diagnosis of multiple sclerosis (MS) or Parkinson's Disease

• Implanted biomedical device (active or inactive implants (including device leads), including deep brain stimulators, cochlear implants, and vagus nerve stimulators)

• History of skull fracture

• Subjects who have any metal implants anywhere in their head, neck or shoulders

• Patients taking any medications, which may influence cortical excitability, which could influence neurophysiologic measures) and affect objective clinical data (e.g. antispastics, anxiolytics, hypnotics, ant-epileptics)

• Subjects who are prescribed medications which may influence cortical excitability, which could influence neurophysiologic measures) and affect objective clinical data (e.g. antispastics, anxiolytics, hypnotics, ant-epileptics), will not be able to remain in the study.

• Unable to provide consent.

Related Conditions & MeSH terms

• Anterior Cruciate Ligament Injuries
• Atrophy
• Muscular Atrophy
• Quadriceps Muscle Atrophy

Intervention

Other:
• Visuomotor Therapy
The use of visual feedback informing internal physiological processes, such as muscle activation, torque, and joint position, has been termed "visuomotor therapy". Visuomotor therapy encompasses completion of sub-maximal motor control tasks accompanying real-time visual biofeedback.
• Passive Motion
The knee is passively moved through a range of motion.

Locations

Country	Name	City	State
United States	University of Virginia	Charlottesville	Virginia

Sponsors (1)

Lead Sponsor	Collaborator
University of Virginia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quadriceps Motor Evoked Potential (micoVolts) PreSham (Passive Motion)	Activation of the Quadriceps muscle through stimulation of primary motor cortex. Measured Through electromyography on the vastus medialis	6-months post-Anterior Cruciate Ligament Reconstruction
Primary	Quadriceps Motor Evoked Potential (micoVolts) PostSham (Passive Motion)	Activation of the Quadriceps muscle through stimulation of primary motor cortex. Measured Through electromyography on the vastus medialis	6-months post-Anterior Cruciate Ligament Reconstruction
Primary	Change in Quadriceps Motor Evoked Potential - Sham (Passive Motion)	Difference in microVolts between pre-sham measure and post-sham measure	6-months post-Anterior Cruciate Ligament Reconstruction
Primary	Quadriceps Motor Evoked Potential (micoVolts) PreActive (Visuomotor Therapy)	Activation of the Quadriceps muscle through stimulation of primary motor cortex. Measured Through electromyography on the vastus medialis	6-months post-Anterior Cruciate Ligament Reconstruction
Primary	Quadriceps Motor Evoked Potential (micoVolts) PostActive (Visuomotor Therapy)	Activation of the Quadriceps muscle through stimulation of primary motor cortex. Measured Through electromyography on the vastus medialis	6-months post-Anterior Cruciate Ligament Reconstruction
Primary	Change in Quadriceps Motor Evoked Potential - Active (Visuomotor Therapy)	Difference in microVolts between pre-active measure and post-active measure	6-months post-Anterior Cruciate Ligament Reconstruction