History of Exposure to Silica or Asbestosis Clinical Trial
Official title:
Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages
Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.
Patients with a proven history or current exposure will have 4 EDTA tubes drawn, approximately 24mL of fresh whole blood for efferocytosis assessment and : - 2 x 6mL serum tubes for the assessment of Antinuclear Antibody (ANA) positivity, serum high-mobility group box 1 (HMGB1) and osteopontin for patients exposed to asbestos - 1 x 6mL serum tube for serum HMGB1 and osteopontin for patients exposed to silica ;