Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Mechanical Ventilation Complication Clinical Trial

Official title:

Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04448782
• Other study ID #: RT COVID-19
• Status: Completed
• Start date: March 9, 2020
• Est. completion date: June 30, 2020

Study information

• Verified date: July 2020
• Source: Corporacion Parc Tauli
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: June 30, 2020
• Est. primary completion date: June 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator

• Diagnosis of COVID-19

Exclusion Criteria:

• less than 48 hours of data,

• age < 18 years

• admitted from other centers under invasive mechanical ventilation.

Related Conditions & MeSH terms

• Mechanical Ventilation Complication

Intervention

Diagnostic Test:
• Asynchronies detection
Asycnhronies detection

Locations

Country	Name	City	State
Spain	Candelaria de Haro	Sabadell	Barcelona

Sponsors (1)

Lead Sponsor	Collaborator
Corporacion Parc Tauli

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation	To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients	during the 5 first days of invasive mechanical ventilation
Secondary	Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation	To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers	From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation
Secondary	Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation	To analyze the incidence of breath stacking and ineffective efforts secondary to RT.	From the day of mechanical ventilation initiation up to 5 days
Secondary	Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation	To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation	Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days
Secondary	Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation	To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival	Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days