Trans Cranial Doppler Ultrasonography in Heamodynamic Optimisation in Septic Shock Clinical Trial
Official title:
Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic
Shock, at the early phase.
patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin
doses:
- Group 1: standard hemodynamic goals and catecholamin infusion to achieve: mean arterial
pressure > or equal to 65 mmHg and diastolic arterial pressure > ou equal to 50 mmHg
within the first 60 minutes.
- Group 2: personalized hemodynamic goals and catecholamin infusion until normal
transcranial doppler: IP<1,2.
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic
Shock, at the early phase.
patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin
doses:
- Group 1: standard hemodynamic goals and cathecolamin infusion to achieve: mean arterial
pressure > or equal to 65 mmHg and diastolic arterial pressure > ou equal to 50 mmHg
within the first 60 minutes.
- Group 2: personalized hemodynamic goals and cathecolamin infusion until normal
transcranial doppler: IP<1,2.
For the 2 groups, standard management including: microbiological sampling, early broad
spectrum anti infective therapy, fluid management and decreasing of blood lactate levels,
will be aimed within the first 60 minutes.
For the Group 2 patients: personalized hemodynamic management will be maintained during 72
hours.
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