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Low Dose Ruxolitinib in Combination With Methylprednisolone

Stem Cell Transplant Complications Clinical Trial

Official title:
Low Dose Ruxolitinib in Combination With Methylprednisolone 1mg/kg as Initial Therapy for Acute Graft-Versus-Host Disease

Clinical Trial Summary

This study is to determine the efficacy and safety of combined Low dose Ruxolitinib With Methylprednisone as Initial Therapy for the aGVHD(acute graft-versus-host disease )

Clinical Trial Description

Corticosteroid is used as a first-line treatment for acute GVHD. However, it is effective in only about half of patients. In this prospective study, the investigators prospectively combined low dose ruxolitinib and 1mg/kg methylprednisolone in the initial treatment of acute GVHD. In order to effectively control GVHD without exposing acute GVHD patients to more intense and prolonged immunosuppression, we used ruxolitinib (20mg/day, 10mg/day, 5mg/day, 2.5mg/day) combined with 1mg/kg methylprednisolone. To ally steroid-related complications, we decreased steroid exposure time (39 days) and cumulative methylprednisolone doses (15.4 mg/kg) to spare the associated toxicity of glucocorticoid therapy. ;

Study Design

Related Conditions & MeSH terms

  • aGVHD
  • Stem Cell Transplant Complications
Clinical Trial Details
NCT number NCT04397367
Study type Interventional
Source Chinese PLA General Hospital
Contact
Status Completed
Phase Phase 1/Phase 2
Start date January 1, 2019
Completion date December 31, 2020
View Details
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