The GLP-1-mediated Gut-kidney Axis Clinical Trial
Official title:
Acute Effects of GLP-1 on Renal Hemodynamics: Simultaneous Perfusion and Oxygenation Measurements in Cortex and Medulla Using Magnetic Resonance Imaging
This study investigates the hypothesis, that GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption, leading to higher tissue oxygenation.
Human studies have recently demonstrated a significant natriuretic effect of GLP-1 when the
extracellular fluid volume (ECFV) is expanded by intravenous sodium-loading; in these
studies, there was a suppression of ANG II with no change in net renal hemodynamics, pointing
to a tubular mechanism for reduced NaCl reabsorption secondary to the ANG II suppression. In
the current randomized and controlled study, investigators aim to test the hypothesis that
GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and
decrease oxygen consumption, leading to higher tissue oxygenation. Thus, contributing to the
renoprotective action of GLP-1.
Under fixed sodium intake for 4 days before each study day, 10 healthy male participants will
be investigated during a 1-hour infusion of GLP-1 (1.5 pmol/kg/min) or vehicle together with
an intravenous infusion of 0.9% NaCl. Interleaved measurements of RAF, oxygenation (T2*) and
perfusion by arterial spin labeling in the renal cortex and medulla at fixed time points will
be conducted, using Magnetic Resonance Imaging (MRI).
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