Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death Clinical Trial

Official title:

Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04321486
• Other study ID #: ISAC18_228
• Status: Active, not recruiting
• Start date: January 1, 1998
• Est. completion date: November 30, 2020

Study information

• Verified date: March 2020
• Source: University College, London
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the dementia incidence, mortality and case-fatality, we implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident dementia.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 4309481
• Est. completion date: November 30, 2020
• Est. primary completion date: May 31, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• We identify individuals aged 30 years or older and registered in the current primary care practice for at least one year.

Exclusion Criteria:

• Individuals are excluded if they had a prior history of dementia before study entry.

Related Conditions & MeSH terms

• Alzheimer Disease
• Dementia
• Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death

Intervention

Other:
• The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.
The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University College, London

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence and mortality of dementia		Jan 1st 1998 - May 31st 2016