Mild to Moderate Alzheimer Disease Clinical Trial
Official title:
Prospective, Randomized, Evaluator-blind, Single Center Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease
The investigators will compare cognitition, mood (depression), ADL, and brain structural and
functional MRI before and after 4-week transcranial magnetic stimulation in patients with
mild to moderate Alzheimer's disease.
The investigators also compare the change of cognitition, mood (depression), ADL, and brain
structural and functional MRI between TMS group and sham coil group.
Each 16 patients will be allocated to TMS group and sham coil group. Before TMS/sham coil
stimulation, the investigators will take fMRI of each patient, and figure out which focus has
strongest connectivity to hippocampus among lateral parietal regions of the brain. The
investigators will fix the TSM transduced and apply accurate TMS stimulation to the focus
using personalized frames. The investigators will make the frame using 3D printing
technology.
After 4 week- TMS stimulation, the investigators will compare cognitition, mood (depression),
ADL, and brain structural and functional MRI beween baseline and after intervention. The
investigators also compare the change of cognitition, mood (depression), ADL, and brain
structural and functional MRI between TMS group and sham coil group.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
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