To Observe the Psychophysiological Alterations in Traumatic Stress Subjects

Traumatic Stress, Post-Traumatic Growth Clinical Trial

Official title:

Effects of the Guided Disclosure Protocol on Post-Traumatic Growth: A Randomized Control Trial Designed to Observe Psychophysiological Alterations in Traumatic Stress Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04217863
• Other study ID #: KU-Psychophysiology-5
• Status: Completed
• Phase: N/A
• Start date: December 2, 2019
• Est. completion date: August 10, 2021

Study information

• Verified date: August 2021
• Source: University of Karachi
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This Multicenter study is planned to investigate the effectiveness of the guided disclosure protocol for the promotion of post-traumatic growth (PTG), in the traumatic stress subjects and to determine whether PTG is associated with psychophysiological alterations i.e. (C-Reactive Protein, Brain Derived Neurotropic Factor, Interlukin-6, Cortisol, Heart Rate Variability and brain waves). Study subjects meeting eligibility criteria will be randomized into two groups. Guided disclosure protocol (GDP) will be used as intervention vs the control. Blinded treatment will be provided and the subjects will be made to complete study questionnaires (Screening, Traumatic Stress Scale SSS, Trauma Symptom Checklist, Post-traumatic growth Inventory) at baseline and at post-intervention (3-months later).

Description:

Study design:

The study will be conducted as multicenter randomized controlled trial. On the basis of eligibility criteria subjects providing consent to participate in the study will be randomized into two groups, experimental group including those who receive the intervention and a control group receiving control intervention. The study outcomes will be monitored in subjects of both groups at different intervals i.e. at baseline and at 3-month follow-up (post-interventional).

Participants Subjects for the present study will be recruited from 5 centers (based in Karachi, Pakistan). The targeted population includes subjects from diverse ethnicity and considered eligible for participation in the study if they indicated in a pre-screening form that they had experienced traumatic event. These subjects will be invited to participate in the study through advertisement on notice board of each center. A written informed consent will be obtained from each study subject after providing detailed information regarding objectives of the study and its duration.

Interventions

The experimental intervention (GDP):

It includes three writing sessions of 20 minutes where the participants will be made to recall the facts regarding the traumatic event first and then the emotions triggered related to the revealed facts will be channelized. The information related to the immediate priority changes due to the revival of the traumatic history and its reflection on current feelings will be collected. Moreover, the learned coping mechanisms will also be inquired and how the traumatic event altered their vision and their personalities and how it helps in coping with future difficulties.

The original instructions will be translated into local language and altered according to the specific traumatic experience.

In the following, a fusion of the tasks concerning each of the three writing sessions is shown.

1. Participants will be required to describe memories associated with traumatic event in a sequential order, with an objective and detached attitude

2. They will be asked to describe

1. Their opinion regarding the traumatic event and emotions perceived during the experience

2. Its impact on their daily lives, and how it has altered their attitudes toward life.

3. The actual situation will be focused, while reviving the whole traumatic event experience which aids in exploring the following aspects:

• Present thoughts and feelings regarding the traumatic experience, and also clarify the differences between the ones felt at the time of traumatic event in comparison to the current feelings.

• How much they understand and appreciate themselves for successfully dealing with the traumatic event

• To what extent the traumatic event has modified their vision, attitude, knowledge, and skills, and how it can help in their future;

• What will be their future reactions to other similar events. For the writing session it is mandatory to maintain standard experimental environment with maximum silence so that the subject can write peacefully without getting disturbed. Two weeks after the initial assessment, the first writing session will be performed followed by two sessions once every 2 weeks.

The control intervention:

In control intervention the subjects will be required to take three 20-minute writing sessions, in which they will be asked to write about their daily events of the past week, the writing must focus on the facts and highlight an objective and detached attitude. It has shown potential improvements after the guided disclosure protocol (GDP). Works through the placebo effect. Same protocol will be followed for these subjects as the one used for GDP.

A day prior to each writing session, in both conditions either experimental or control the researcher will communicate with each study subject via telephone in order to give them a reminder to perform the writing task and to check their understanding regarding the instructions given in the booklet. Details regarding the inability to contact the subject will also be recorded in the patient form.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 246
• Est. completion date: August 10, 2021
• Est. primary completion date: August 10, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

1. Must be disease free, there must be no evidence of any metastatic disease

2. Property of written and spoken the English language.

3. Experienced any traumatic event in the last 12 Months

Exclusion Criteria:

1. Subjects who received a structured psychological intervention for at least 6 months during the last 3 years performed by a psychologist or psychiatrist will be excluded.

2. Those with a codified psychiatric disorder (according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) who received Psychopharmacological treatment during the last 3 years will also be excluded from the study sample.

Related Conditions & MeSH terms

• Traumatic Stress, Post-Traumatic Growth

Intervention

Behavioral:
• GDP
Guided Disclosure Protocol

Locations

Country	Name	City	State
Pakistan	Shamoon Noushad	Karachi	Sindh

Sponsors (2)

Lead Sponsor	Collaborator
University of Karachi	Advanced Education & Research Center

Country where clinical trial is conducted

Pakistan, 

References & Publications (8)

Alper B, Erdogan B, Erdogan MÖ, Bozan K, Can M. Associations of Trauma Severity with Mean Platelet Volume and Levels of Systemic Inflammatory Markers (IL1ß, IL6, TNFa, and CRP). Mediators Inflamm. 2016;2016:9894716. doi: 10.1155/2016/9894716. Epub 2016 Apr 5. — View Citation

Cai WP, Pan Y, Zhang SM, Wei C, Dong W, Deng GH. Relationship between cognitive emotion regulation, social support, resilience and acute stress responses in Chinese soldiers: Exploring multiple mediation model. Psychiatry Res. 2017 Oct;256:71-78. doi: 10.1016/j.psychres.2017.06.018. Epub 2017 Jun 8. — View Citation

Gandubert C, Scali J, Ancelin ML, Carrière I, Dupuy AM, Bagnolini G, Ritchie K, Sebanne M, Martrille L, Baccino E, Hermès A, Attal J, Chaudieu I. Biological and psychological predictors of posttraumatic stress disorder onset and chronicity. A one-year prospective study. Neurobiol Stress. 2016 Feb 4;3:61-67. eCollection 2016 Jun. — View Citation

Gidron Y, Duncan E, Lazar A, Biderman A, Tandeter H, Shvartzman P. Effects of guided written disclosure of stressful experiences on clinic visits and symptoms in frequent clinic attenders. Fam Pract. 2002 Apr;19(2):161-6. — View Citation

Kalisch R, Müller MB, Tüscher O. A conceptual framework for the neurobiological study of resilience. Behav Brain Sci. 2015;38:e92. doi: 10.1017/S0140525X1400082X. Epub 2014 Aug 27. Review. — View Citation

Linz R, Puhlmann LMC, Apostolakou F, Mantzou E, Papassotiriou I, Chrousos GP, Engert V, Singer T. Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training. Neuropsychopharmacology. 2019 Sep;44(10):1797-1804. doi: 10.1038/s41386-019-0391-y. Epub 2019 Apr 16. — View Citation

Liu AN, Wang LL, Li HP, Gong J, Liu XH. Correlation Between Posttraumatic Growth and Posttraumatic Stress Disorder Symptoms Based on Pearson Correlation Coefficient: A Meta-Analysis. J Nerv Ment Dis. 2017 May;205(5):380-389. doi: 10.1097/NMD.0000000000000605. Review. — View Citation

Smith HE, Jones CJ, Hankins M, Field A, Theadom A, Bowskill R, Horne R, Frew AJ. The effects of expressive writing on lung function, quality of life, medication use, and symptoms in adults with asthma: a randomized controlled trial. Psychosom Med. 2015 May;77(4):429-37. doi: 10.1097/PSY.0000000000000166. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Trauma Symptom Checklist 40 (TSC-40)	Change in the Trauma Symptom Checklist 40 (TSC-40) will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Other	Traumatic Stress Scale (Sadaf Stress Scale)	Change in the Traumatic Stress Scale will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Primary	Post-Traumatic Growth (PTG)	Change in the Post-traumatic Growth Inventory (PTGI) will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	C- Reactive Protein (CRP)	Change in the CRP level will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Brain-derived neurotrophic factor (BDNF)	Change in the BDNF level will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Interleukin-6 (IL-6)	Change in the IL-6 level will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Glutamate	Change in the Glutamate level will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Cortisol	Change in the Cortisol level will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Alpha waves	Change in the Brain waves (Alpha waves) will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Heart Rate Variability	Change in the Heart Rate Variability will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months
Secondary	Beta waves	Change in the Brain waves (Beta waves) will be observed among the subjects enrolled in the GDP group as compared to the control group.	3 Months