Multiresistant Bacterial Pathogens Clinical Trial
Official title:
Development of a Swiss Surveillance Database for Molecular Epidemiology of Hypervirulent and Multi-drug Resistant Pathogens
Hypervirulent and multidrug-resistant infections are associated with significant health care costs, substantial morbidity and mortality. Therefore, the rapid recognition of outbreaks and transmissions with hypervirulent and multi-drug resistant pathogen is a key priority for infection control and public health.The main goal is to implement a shared database, connecting human and veterinary microbiology laboratories, which would allow near real-time molecular epidemiology with high spatiotemporal resolution of bacterial pathogens such as transmission and outbreak surveillance between different compartments including humans, animals and the environment in Switzerland. Investigator aims to analyze already collected encoded retrospective datasets of various pathogens by combining epidemiological data and whole genome sequences from pathogens.
| Status | Recruiting |
| Enrollment | 10000 |
| Est. completion date | December 31, 2029 |
| Est. primary completion date | December 31, 2029 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | N/A and older |
| Eligibility | Inclusion Criteria: - All patients with either colonisations or infections with either a bacterial or a viral pathogen, where whole genome sequencing data and available minimal epidemiological, demographic and clinical data - Pathogens included into analysis are: Multidrug-resistant bacteria include: methicillin resistant Staphylococcus aureus (MRSA), Carbapenemase- and/or extended spectrum betalactamase (ESBL)-producing Enterobacteriaceae and non-fermenting bacteria including Pseudomonas aeruginosa and Acinetobacter baumannii, Vancomycin resistant Enterococcus faecium, and others; virulent bacteria include: Neisseria meningitidis, Neisseria gonorrhoeae, Mycobacterium tuberculosis, Campylobacter spp., Salmonella spp., Legionella pneumophila, Listeria monocytogenes, and Streptococcus pneumoniae, and others; Viruses include: Influenza viruses, Measles virus, Enterovirus E68, Respiratory Syncytial Virus and others. Exclusion Criteria: - Decline to sign a general consent or any other declining statement against using data for research purposes. |
| Country | Name | City | State |
|---|---|---|---|
| Switzerland | University Hospital Basel | Basel | |
| Switzerland | University of Bern | Bern | |
| Switzerland | University Hospital Geneva | Geneva | |
| Switzerland | University Hospital Lausanne CHUV | Lausanne | |
| Switzerland | University of Zurich | Zurich |
| Lead Sponsor | Collaborator |
|---|---|
| University Hospital, Basel, Switzerland | Swiss National Science Foundation |
Switzerland,
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* Note: There are 13 references in all — Click here to view all references
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Identification of transmission clusters based on genetic similarity. | Identification of transmission clusters based on genetic similarity. With focus on whole genome sequencing. | Onetime identification at baseline | |
| Secondary | Detection of Genotypic Resistance | Detection of Genotypic Resistance (in-vitro antibiotic susceptibility test (AST) based on measuring minimum inhibitory concentration (MIC) or zone diameter (ZD)) | Onetime identification at baseline |