Participants of the Be-MaGIC-Study 2009 Clinical Trial
Official title:
Prospective Long Term Follow-up Analysis of Exercise-induced Physiological Changes in Male Runners
Pro-MagIC is a prospective observational study and includes participants of the Be-MaGIC-Study 2009 (n=277/NCT00933218). We aim to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years.
Physical activity is associated with health benefits. Acute prolonged and strenuous exercise,
i.e. Marathon running, leads to hemodynamic, endothelial and myocardial functional changes.
Whether these myocardial, endothelial and hemodynamic changes can also develop and persist
through repetitive extreme and prolonged physical activity is currently still a matter of
controversy. In addition, it is not known whether adaptations and changes over time can
develop into clinically relevant cardiovascular events with negative health consequences in
healthy athletes. The aim of this study is to detect exercise-induced physiological changes
(inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a
period of 10 years.
For this purpose, 277 male participants from the Be-MaGIC study (Marathon 2009) are examined
in this prospective observational study. A single examination with the following components
will take place: Anthropometry, clinical examination, laboratory, resting / exercise
electrocardiography cardiopulmonary stress test, echocardiography, and fundus camera. Further
examinations will be conducted in participants with abnormal examination results in line with
current clinical recommendations.
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