Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor (Disorder) Clinical Trial
Official title:
A Phase Ib Study to Evaluate the Safety and Efficacy of Osimertinib in Combination With Ipilimumab in Patients With EGFR Mutated Non-Small-Cell Lung Cancer Tumors
This is a prospective, open label, interventional trial beginning with a phase 1b safety run-in followed by an expansion cohort.
The primary objective is to assess the short and long term tolerability of ipilimumab in combination with osimertinib. The secondary objective is to assess efficacy of osimertinib in combination with ipilimumab. Ipilimumab will be given for a total of four doses and osimertinib will be given until treatment discontinuation criteria is met. Ipilimumab at the assigned dose level every 3 weeks for four doses in combination with once daily osimertinib. ;