MARC-2: MARKERS AND RESPONSE TO CRT in Non-LBBB

Cardiac Resynchronization Therapy, Non-LBBB, QRS Area Clinical Trial

— MARC-2  

Official title:

MARC-2: MARKERS AND RESPONSE TO CRT in Non-LBBB

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04120909
• Other study ID #: 2018-0863
• Status: Recruiting
• Start date: August 26, 2019
• Est. completion date: August 2022

Study information

• Verified date: October 2019
• Source: Maastricht University Medical Center
• Contact: Kevin Vernooy, dr.
• Phone: +31(0)433877095
• Email: kevin.vernooy[@]mumc.nl
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of the MARC-2 study is to investigate the relation of the QRS area, determined by vectorcardiography, and response to Cardiac Resynchronization Therapy (CRT) in patients with a wide QRS complex and without a typical left bundle branch block; the interrelationship as well as the potential predictive power of this biomarker, as well as other clinical biomarkers on a hierarchal composite endpoint (death, heart failure hospitalizations, heart failure complaints and cardiac function) will be evaluated.

The main biomarker that is studied is the QRS area, but also other electrocardiographic, echocardiographic markers, blood markers and clinical markers will be studied.

Description:

For the purpose described in the brief summary, the MARC-2 study investigators have set an aim of including 800 patients in 2 inclusion years, in 30 centres accross Europe and Israel. Inclusion will be general patients indicated for (de novo or upgrade) implantation a (Medtronic) CRT-pacemaker or -ICD, as according to current ESC heart failure guidelines. Exclusion criteria are, age below 18 years, (planning) childbearing, baseline > 5% RV-pacing, listing for transplantation or inotropic dependency, structural heart disease for which invasive therapy is pending, or inability/unwillingness to sign written informed consent. All QRS morphologies, with duration >/= 130ms are included because multiple LBBB definitions exist and excluding patients on one definition will leave room for questions about the definitions used. (Bio)markers that are collected are electrocardiographic/vectorcardiographic/echocardiographic/blood-/CMR/ and device-based parameters that have shown prior association to outcomes in CRT, with special attention to vectorcardiographic QRS area. The primary endpoint will be a hierarchal (Packer) score of collected heart failure related endpoints including death/LVAD/cardiac transpland/heart failure hospitalizations/echocardiographic remodelling and NYHA improvement. Follow-up for clinical endpoints will be 12 months; with echocardiographic follow-up at 6 months. Clinical endpoints are subject to adjudication committee assessment. Core-labs exist to assess electrocardiographic, echocardiographic and CMR-data.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 800
• Est. completion date: August 2022
• Est. primary completion date: August 2022
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Subject is scheduled to be implanted with a CRT-pacemaker or CRT-defibrillator

• Subject has NYHA class I, II, III or ambulant IV

• Subject has LV dysfunction (LVEF</=35%)

• Subject is in sinus rhythm on an ECG less than 45 days before CRT implantation

• Intrinsic QRS duration is >/=130ms (of either QRS morphology) within 30 days prior to CRT device implantation

• Subject receives optimal heart failure oral medical therapy (ACE inhibitor and/or ARB and Beta Blockers), and is on a stable medication scheme for at least 1 month prior to enrolment

• Subject is willing to sign informed consent form

• Subject is 18 years or older

Exclusion Criteria:

• Subject has a pacemaker/ICD with >5% RV pacing.

• Subject receives CRT-D replacement or is upgraded from CRT-P to CRT-D

• Subject experienced a recent myocardial infarction, within 40 days prior to enrollment

• Subject underwent coronary artery bypass graft (CABG) or valve surgery, within 90 days prior to enrollment

• Subject is post heart transplantation, or is actively listed on the transplantation list, or has reasonable probability (per investigator's discretion) of undergoing transplantation in the next year

• Subject is implanted with a left ventricular assist device (LVAD), or has reasonable probability (per investigator's discretion) of receiving a LVAD in the next year

• Subject is on continuous or uninterrupted infusion (inotropic) therapy for heart failure

• Subject has permanent 2nd or 3rd degree AV-block

• Subject has severe aortic stenosis (with a valve area of <1.0 cm2 or significant valve disease expected to be operated within study period)

• Subject has complex and uncorrected congenital heart disease

• Subject has a mechanical right heart valve

• Subject has a life expectancy of less than one year in the opinion of the investigator

• Pregnant or breastfeeding women, or women of child bearing potential and who are not on a reliable form of birth control

• Subject is enrolled in one or more concurrent studies that would confound the results of this study

Related Conditions & MeSH terms

• Cardiac Resynchronization Therapy, Non-LBBB, QRS Area

Intervention

Device:
• Cardiac resynchronization therapy
Biventricular pacing according to current standards.

Locations

Country	Name	City	State
Netherlands	Maastricht UMC+	Maastricht

Sponsors (2)

Lead Sponsor	Collaborator
Maastricht University Medical Center	Medtronic

Country where clinical trial is conducted

Netherlands, 

References & Publications (1)

van Stipdonk AMW, Ter Horst I, Kloosterman M, Engels EB, Rienstra M, Crijns HJGM, Vos MA, van Gelder IC, Prinzen FW, Meine M, Maass AH, Vernooy K. QRS Area Is a Strong Determinant of Outcome in Cardiac Resynchronization Therapy. Circ Arrhythm Electrophysi — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	CRT response score will assess patient improvement including all-cause mortality, heart failure hospitalization, LVESVi reduction, and NYHA class improvement	Hierarchical endpoint based upon the concepts presented by Packer (Packer, Circulation 2016)	12 months