End Stage Renal Disease on Dialysis Clinical Trial
Official title:
The Influences of Dialysate Bicarbonate Concentrations on Hemodialysis Patients
Background:
Patients with decreased kidney function are in the positive acid balance due to insufficient
renal acid excretion. To correct the varying degrees of metabolic acidosis in these HD
patients, a high concentration of HCO3 in the dialysate is routinely used.
During every 3-to-4 hours of HD treatment, a massive surge of HCO3 would enter the
circulation and typically overcorrects predialysis acidosis to alkalosis and alkalemia.
The sharp acid-base shift can cause some adverse consequences.
The investigators believe that the rapid correction (or overcorrection) from the pre-dialysis
metabolic acidosis to post-dialysis metabolic alkalosis during the 3-to-4 hours HD treatment
would relate to adverse effects on HD patients.
Thus the investigators conduct this study to prove the hypothesis that "prevention of
post-dialysis alkalosis by using lower dialysate HCO3 concentration might cause less adverse
outcomes in ESRD patients on HD."
Study design:
Prospective cross-over case-control study.
Study population:
A total of 60 patients who receive regular hemodialysis (three times per week) for more than
6 months in the regional teaching hospital.
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