Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France. — F3S

Fuchs Endothelial Corneal Dystrophy Clinical Trial

Official title:
Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France. The French Fuchs' Follow-up Study, F3S

Status Completed

Clinical Trial Summary

The pathophysiology of the most common corneal endothelial dystrophies (Fuchs' Corneal Endothelial Dystrophy (FECD)) is beginning to be dismembered. One of the most common genetic anomalies is a triplet repetition in one of the introns of the Transcription Factor 4 (TCF4) gene located on chromosome 18. However, the number of repetitions varies greatly from one patient to another.

Clinical Trial Description

The intent of that study was to analyse if there is a relationship between the number of triplet repetitions and the rate of disease progression. This knowledge would make it possible to personalize the care. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03974230
Study type	Observational
Source	Centre Hospitalier Universitaire de Saint Etienne
Contact
Status	Completed
Phase
Start date	August 1, 2019
Completion date	December 14, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04440280` - Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy	Phase 2
Active, not recruiting	`NCT05376176` - A Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD)	Phase 2
Recruiting	`NCT05826353` - A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)	Phase 3
Recruiting	`NCT04387331` - The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
Recruiting	`NCT05795699` - A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)	Phase 3
Active, not recruiting	`NCT04894110` - Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema	Phase 1
Completed	`NCT04520321` - A Phase 1/ Phase 2 Study of TTHX1114(NM141)	Phase 1/Phase 2
Withdrawn	`NCT05052554` - Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3	Phase 1