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OCT Explores Vascular Response and Healing Profile After Stenting in CTO

Chronic Total Occlusion of Coronary Artery Clinical Trial

Official title:
Optical Coherence Tomography Imaging Explores Long-term vasculAR Response and Healing profIle After successFul coronarY Stenting in Chronic Total Occlusion

Clinical Trial Summary

True-false-true occurred during wire penetration in coronary CTO procedure. Subintimal stenting influences vascular response. Intravenous ultrasound confirmed wire position in the procedure. Then stenting procedure was performed. Optical coherence tomography was used for exploring long-term vascular response and healing profile after successful coronary stenting in CTO lesions.

Clinical Trial Description

Chronic total occlusions (CTOs) are defined as coronary lesions with thrombolysis in myocardial infarction (TIMI) grade flow of 0 and present for more than 3 months. CTO is commonly recognized as the toughest lesion subset to be treated by percutaneous coronary interventions. With the remarkable progress in the technologies and techniques achieved in the PCI for CTO over the last decade, the rate of procedural success increased to 80-90%. Chronic total occlusion is associated with a higher incidence of malapposition and uncovered stent struts. At present, four strategies were used for CTO lesions, including: ante-grade wire escalation, ante-grade dissection reentry (ADR), retro-grade wire escalation, and retrograde dissection reentry (RDR). True-false-true occurred during wire penetration. Subintimal stenting influences vascular response. Intravenous ultrasound (IVUS) confirmed wire position in the procedure. Then stenting procedure was performed according to standard routine. Optical coherence tomography (OCT) was used for exploring long-term vascular response and healing profile after successful coronary stenting in CTO lesions. ;

Study Design

Related Conditions & MeSH terms

  • Chronic Total Occlusion of Coronary Artery
Clinical Trial Details
NCT number NCT03939299
Study type Interventional
Source Shanghai Zhongshan Hospital
Contact Hongbo Yang, M.D.
Phone 008613585890793
Email yang.hongbo@zs-hospital.sh.cn
Status Recruiting
Phase N/A
Start date April 15, 2019
Completion date December 31, 2023
View Details
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