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Early Assessment of Response to Treatment of Metastatic LUng Tumors Based on CIrculating Tumor DNA — ELUCID  

Metastatic Non-small Cell Lung Cancer Clinical Trial

Official title:
Non-controlled Prospective Pilot Study Assessing Prognostic Performance of Circulating Tumour DNA Kinetic Analysis for Monitoring Response to Treatment of Metastatic Non-small Cell Lung Cancers

Clinical Trial Summary

In patients with locally advanced or metastatic tumors, first-line therapeutic management is based on the use of targeted therapies (EGFR, BRAF ALK and ROS1 inhibitors), immunotherapies (anti-PD1/ anti-PDL1-antibodies or chemotherapy. Despite patient selection based on histo-pathological and molecular criteria, not all patients respond to treatment. There are currently no markers to definitively guarantee a patient's response. An alternative is to identify early patient response to treatment. The investigator hypothesize that change in circulating tumor DNA concentration (ctDNA) allow to early identify patients' therapeutic response (and non-response) of patients, regardless of the type of treatment used in the first line setting.

Clinical Trial Description

The primary objective is to determine whether early evolution (between baseline and week 3) of circulating tumor DNA concentration predicts the radiological response to first-line treatment of advanced or metastatic NSCLC patients, regardless of treatment ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03926260
Study type Interventional
Source Centre Hospitalier Departemental Vendee
Contact
Status Completed
Phase N/A
Start date June 27, 2019
Completion date May 23, 2022
View Details
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