Normal Healthy Volunteers Without Chronic Medical Conditions Clinical Trial
— PET NormalsOfficial title:
Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers
To establish quantitative values of myocardial blood flow (MBF) in normal, healthy volunteers .
Status | Not yet recruiting |
Enrollment | 20 |
Est. completion date | September 30, 2019 |
Est. primary completion date | September 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Adults =18 and <40 years old - Participants must be able to give informed consent. - Ability to abstain from caffeine for 48 hours Exclusion Criteria: - Any chronic cardiac disease or condition (e.g. hypertension, hyperlipidemia) - Any chronic systemic disease or condition (e.g. diabetes, systemic lupus, rheumatoid arthritis) - Tobacco use - Family history in a first degree relative with clinical coronary artery disease (history of myocardial infarctio, percutaneous intervention or coronary artery bypass grafting) in men <55 years old or women <65 years old - Severe claustrophobia - Positive urine pregnancy test - Inability to give informed consent |
Country | Name | City | State |
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United States | Ochsner | New Orleans | Louisiana |
Lead Sponsor | Collaborator |
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Ochsner Health System |
United States,
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Renaud JM, DaSilva JN, Beanlands RS, DeKemp RA. Characterizing the normal range of myocardial blood flow with 8²rubidium and ¹³N-ammonia PET imaging. J Nucl Cardiol. 2013 Aug;20(4):578-91. doi: 10.1007/s12350-013-9721-3. Epub 2013 May 9. Erratum in: J Nucl Cardiol. 2013 Aug;20(4):702. — View Citation
Renaud JM, Yip K, Guimond J, Trottier M, Pibarot P, Turcotte E, Maguire C, Lalonde L, Gulenchyn K, Farncombe T, Wisenberg G, Moody J, Lee B, Port SC, Turkington TG, Beanlands RS, deKemp RA. Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow. J Nucl Med. 2017 Jan;58(1):103-109. doi: 10.2967/jnumed.116.174565. Epub 2016 Aug 18. — View Citation
Sdringola S, Johnson NP, Kirkeeide RL, Cid E, Gould KL. Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers. JACC Cardiovasc Imaging. 2011 Apr;4(4):402-12. doi: 10.1016/j.jcmg.2011.02.008. — View Citation
Type | Measure | Description | Time frame | Safety issue |
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Primary | Absolute myocardial blood flow at rest and stress in cc/min/g | resting and stress MBF are in units of cc/min/g | measured at the time of the cardiac PET stress scan |
Status | Clinical Trial | Phase | |
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Completed |
NCT05286593 -
3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
|
Phase 4 |