Different Modes of Ventilation During Cardiopulmonary Bypass

Postoperative Pulmonary Dysfunction Clinical Trial

Official title:

Comparative Study Between Different Modes of Ventilation During Cardiopulmonary Bypass and Its Effect on Postoperative Pulmonary Dysfunction

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03824301
• Other study ID #: ASCSH32/17
• Status: Completed
• Phase: N/A
• Start date: January 22, 2017
• Est. completion date: November 20, 2018

Study information

• Verified date: January 2019
• Source: Ain Shams University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

66 patients divided into 3 groups with different modes of ventilation.

Description:

Sixty-six patients going through open-heart surgeries were included in the study, divided into 3 groups (P: pressure controlled ventilation, V: volume controlled ventilation, C: control) in accordance with the mode of ventilation. Patients studied for chest x-ray, lung ultrasound, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2), Alveolar-arterial oxygen gradient, static lung compliance and dynamic lung compliance, taken after induction of anesthesia, 1h post cardiopulmonary bypass, 1h after arrival to cardiac surgical unit.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 66
• Est. completion date: November 20, 2018
• Est. primary completion date: March 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients undergoingvalve surgeries

• Patients undergoing coronary artery bypass grafting surgeries

Exclusion Criteria:

• Emergency cases.

• Off-pump surgeries.

• Patients with chronic lung diseases with forced expiratory volume in first second (FEV1) or forced vital capacity (FVC) less than 40% of the predicted value.

• Massive blood transfusion during surgery.

• Complicated surgeries.

• Redo surgeries.

• Patients with decompensated heart failure prior to surgery.

• Patients refusal

Related Conditions & MeSH terms

• Postoperative Pulmonary Dysfunction

Intervention

Device:
• Volume controlled ventilation
Changing modes of ventilation during cardiopulmonary bypass
• Pressure controlled ventilation
Applying pressure controlled ventilation during cardiopulmonary bypass Period

Locations

Country	Name	City	State
Egypt	Ain Shams University cardiothoracic hospital	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	chest x-ray	Chest x ray to detect any lung pathology or changes from baseline like pleural effusion, pulmonary edema or pneumonia	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.
Primary	lung ultrasonography	Lung ultrasonography to detect any lung changes from baseline or development of consolidation, pulmonary edema or pleural effusion	after induction of anesthesia, 1hour post cardiopulmonary bypass and 1hour after arrival to cardiac surgical unit.