Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

Postoperative Cognitive Dysfunction Clinical Trial

Official title:

Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03703973
• Other study ID #: POCDLTL
• Status: Recruiting
• Start date: August 1, 2016
• Est. completion date: December 31, 2020

Study information

• Verified date: October 2018
• Source: Xuzhou Medical University
• Contact: Junli Cao
• Phone: +86 15162160809
• Email: caojl0310[@]yahoo.com.cn
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

• Non-cardiac surgery patients;

• Age is greater than or equal to 65 years old;

• Han Nationality, mother tongue is chinese;

?The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

?The Geriatric Depression Scale (GDS) grade 1 or 2;

?The important function without serious heart, brain, liver, kidney, lung and other organs;

• The ASA class I or II;

• The people signed informed consent.

Exclusion Criteria:

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ?Had severe head and face disease, trauma history or history of surgery;

• Had a history of influenza in 3 weeks; ?The serious body disease and tobacco, wine and other substance abuse history; ?The presence of malignant tumor with shorter survival disease.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Postoperative Cognitive Dysfunction

Intervention

Diagnostic Test:
• Neuropsychology test
We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.

Locations

Country	Name	City	State
China	Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University	Xuzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Xuzhou Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the neuropsychological test to measure cognitive function		1 day before surgery(baseline)
Primary	Mini-Mental score examination [MMSE] used for screening of dementia		1 day before surgery(baseline)
Primary	the leukocyte telomere length		on the surgery day
Primary	the neuropsychological test to measure cognitive function		within the first 7 days (plus or minus 2 days) after surgery
Primary	Mini-Mental score examination [MMSE] used for screening of dementia		within the first 7 days (plus or minus 2 days) after surgery
Primary	the neuropsychological test to measure cognitive function		within the first 3 months (plus or minus 1 month) after surgery
Primary	Mini-Mental score examination [MMSE] used for screening of dementia		within the first 3 months (plus or minus 1 month) after surgery
Primary	the neuropsychological test to measure cognitive function		within the first 1 year (plus or minus 3 months) after surgery
Primary	Mini-Mental score examination [MMSE] used for screening of dementia		within the first 1 year (plus or minus 3 months) after surgery
Primary	the neuropsychological test to measure cognitive function		within the first 3 years (plus or minus 1 year) after surgery
Primary	Mini-Mental score examination [MMSE] used for screening of dementia		within the first 3 years (plus or minus 1 year) after surgery