Functional Residual Capacity Measured by Capnography in Ventilated Patients

Respiratory Physiological Phenomena Clinical Trial

Official title:

Effect of Positive End-expiratory Pressure on Functional Residual Capacity Measured by Volumetric Capnography in Mechanically Ventilated Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03693352
• Other study ID #: 2919/1728/18
• Status: Completed
• Start date: October 1, 2018
• Est. completion date: April 1, 2020

Study information

• Verified date: February 2020
• Source: Hospital Privado de Comunidad de Mar del Plata
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Changes in body position during anesthesia can alter functional residual capacity and gas exchange. The monitoring of such changes in functional residual capacity is difficult at the bedside. The present study was designed to determine if volumetric capnography can detect changes in the functional residual capacity during surgery.

Description:

This is a prospective and observational study designed to test the reliability of the capnodynamic equation to determine changes in functional residual capacity measured during anesthesia. The investigators will studied 40 mechanically ventilated patients undergoing general anesthesia. Functional residual capacity will be continuously measured in a non invasive way using expired carbon dioxide. Changes in functional residual capacity with standard modification in body positioning (Trendelenburg or anti-Trendelenburg position) and ventilatory settings wiil be tested.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: April 1, 2020
• Est. primary completion date: February 10, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 30 Years to 80 Years

Eligibility

Inclusion Criteria:

• Written Inform Consent

• Programmed surgery

• Laparoscopic surgery

• Supine position

Exclusion Criteria:

• Emergency surgery

• Chronic respiratory disease

• Active smoking

Related Conditions & MeSH terms

• Respiratory Physiological Phenomena

Locations

Country	Name	City	State
Argentina	Hospital Privado de Comunidad	Mar del Plata	Buenos Aires

Sponsors (1)

Lead Sponsor	Collaborator
Hospital Privado de Comunidad de Mar del Plata

Country where clinical trial is conducted

Argentina, 

References & Publications (1)

Albu G, Wallin M, Hallbäck M, Emtell P, Wolf A, Lönnqvist PA, Göthberg S, Peták F, Habre W. Comparison of static end-expiratory and effective lung volumes for gas exchange in healthy and surfactant-depleted lungs. Anesthesiology. 2013 Jul;119(1):101-10. doi: 10.1097/ALN.0b013e3182923c40. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Functional Residual Capacity Measured by Capnography in Ventilated Patients	Measurement of functional residual capacity with capnography with body positioning changes.	6 hours