Skin Sympathetic Nerve Activity During General Anesthesia in Patients Undergoing Breast Cancer Surgery Clinical Trial
Official title:
Recording Sympathetic Nerve Activity From the Skin During Surgery Under General Anesthesia : a Pilot Study
| Verified date | February 2019 |
| Source | Seoul National University Hospital |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
Sympathetic nerve activity can be measured transcutaneously in awake patients by
computer-based filtering of raw signal obtained via skin leads attached on the chest.
Electrocardiogram can be removed by applying a high-pass filter setting of 150 Hz.
Electromyogram can be filtered by applying a high-pass filter setting of 500 Hz or a
band-pass filter setting of 500-1000 Hz.
However, it is not known whether the skin sympathetic nerve activity (SKNA) can be measured
in anesthetized and/or paralyzed patients. Therefore, we planned this pilot study to observe
whether the SKNA can be obtained in these patients. If the SKNA ca be observed, it will be
presented in milivolt (uV).
| Status | Completed |
| Enrollment | 20 |
| Est. completion date | November 1, 2018 |
| Est. primary completion date | November 1, 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 20 Years and older |
| Eligibility |
Inclusion Criteria: - patients scheduled to undergo resection of breast cancer under general anesthesia after insertion of laryngeal mask airway Exclusion Criteria: - Autonomic nervous system disease - Medication acting on the autonomic nervous system - Refuse to participate |
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | Seoul National University Hospital | Seoul |
| Lead Sponsor | Collaborator |
|---|---|
| Seoul National University Hospital |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | The skin sympathetic nerve activity presented as uV obtained via skin leads. | A few studies reported that skin sympathetic nerve activity (SKNA) signal could be potentially observed by applying a high-pass filter of 500 Hz or a band-pass filter of 500~1000 Hz to electric signal from skin leads attached on the skin of the chest in awake volunteers. However, it is not known if it would be also possible to observe the SKNA signal in anesthetized patients. Also, there is no established method for quantitative or qualitative assessment of the SKNA signal. | During surgery/anesthesia |