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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT03655769
Other study ID # NA_00045404
Secondary ID R01AG021501
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date November 9, 2010
Est. completion date December 31, 2024

Study information

Verified date January 2024
Source Johns Hopkins University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Cathodal Transcranial direct current stimulation (tDCS) was administered to the right parietal region in order to determine if this stimulation could disrupt awareness of the conditioned stimulus (CS) - unconditioned stimulus (US) relationship in a classical conditioning experiment.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 16
Est. completion date December 31, 2024
Est. primary completion date December 31, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 30 Years
Eligibility Inclusion Criteria: - Educational attainment of at least eight years and English as the native language - Mini-Mental State Examination (MMSE) score of 26 - Normal episodic memory (i.e., CERAD word List Recall > 5) - Informed consent; 5) age of 20-30 Exclusion Criteria: - Disturbed consciousness - Other neurological or systemic disorder which can cause dementia or cognitive dysfunction - Prior history of a major psychiatric disorder - History of definite stroke - Focal lesion on MRI exam - Use of anxiolytic, antidepressant, neuroleptic, or sedative medication - Predominately left-handed - Has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).

Study Design


Related Conditions & MeSH terms

  • Transcranial Direct Current Stimulation

Intervention

Device:
transcranial direct current stimulation
transcranial direct current stimulation applied at 2 mA over the right parietal region for 20 min
sham transcranial direct current stimulation
transcranial direct current stimulation applied at 2 mA over the right parietal region for 30 sec

Locations

Country Name City State
n/a

Sponsors (2)

Lead Sponsor Collaborator
Johns Hopkins University National Institute on Aging (NIA)

Outcome

Type Measure Description Time frame Safety issue
Primary CS-US Awareness To assess CS-US awareness, we used a questionnaire The questionnaire consists of 7 true/false questions about the sequence and co-occurrence of the conditioned stimulus (CS, a 1000 Hz tone) and unconditioned stimulus (US, a 100 ms puff of air to the eye). The score can thus range from 0 to 7. Higher score values indicate better awareness of the sequence and co-occurrence of the CS and US recorded immediately after the 20 minutes of tDCS stimulation
Secondary Line bisection test of left-hemifield neglect The subject is given a sheet of paper with a number of horizontal lines on it. The subject is instructed to cut each line in half by drawing a small pencil mark through each line. The test is scored by measuring the percent deviation, which is calculated by the following formula:
Percent deviation=100 x (measured left half - true half)/true half This yields positive numbers for marks placed to the right of center, and negative numbers for marks placed to the left of center. Patients with right hemisphere damage and contralateral neglect show higher positive line bisection scores compared to healthy controls or patients without right hemisphere damage and vice versa.
recorded immediately after primary awareness questionnaire
Secondary Eyeblink conditioned responding Eyeblink conditioning is recorded while the subject watches a silent movie. For conditioning, the conditioned stimulus (CS) is a 1350 ms 1000 Hz tone. This tone co-terminates with a 100 ms left corneal airpuff (5 psi). 30 CS-US presentations are delivered at an average rate of one every 18 sec. Conditioned responses (CRs) are defined as follows: the difference between the maximum and minimum responses in a 500 ms pre-US time window must exceed four times the standard deviation of the mean of the baseline period (250 ms pre-CS presentation). The 500 ms pre-US time window was selected to minimize the inclusion of voluntary and alpha responses as CRs. Performance is expressed as % CRs, that is, the percent of trials in which a CR occurred. Greater numbers indicate greater amounts of learning. recorded during the tDCS administration
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