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Clinical Trial Summary

The aim of this study is to complete the identification of genetic factors predisposing to thyroid associated ophthalmopathy (TAO) by constituting a cohort of 400 Grave's patients with or without ocular signs.


Clinical Trial Description

Graves' disease (GD) is a common autoimmune condition, and its ocular condition is known as thyroid-associated ophthalmopathy (TAO). There is considerable evidence that both genetic and environmental factors are involved in the development of TAO. We conduct a study of 400 Grave's patients, with or without TAO, and obtain the following data: genetic tests, ocular imaging and life style information. Genetic tests are obtained by collection of blood samples for DNA extraction, whole-genome sequencing, and identification of cellular biomarkers, using transcriptomics and mass cytometry. Ocular imaging data are collected from Orbit MRI examination. Life style data are collected using a standardized questionnaire. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03515863
Study type Observational
Source Sun Yat-sen University
Contact Yingfeng Zheng
Phone +8613922286455
Email zhyfeng@mail.sysu.edu.cn
Status Recruiting
Phase
Start date May 15, 2018
Completion date May 9, 2022

See also
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