Hyperspectral Imaging Data of Excreta Clinical Trial
— HINEDOfficial title:
Utilize Hyperspectral Imaging to Reveal the Possible Clues of Neoplasm for Early Stage Detection
Background Information With the advance in cancer biology, we realize that malignant neoplasm
is related with different biological patterns in metabolome and microbiota. Because of the
progress in optical spectrometry, it has become possible to evaluate whole visible and
innon-visiable absorptive spectrum in human specimens, which may enable detection of minor
changes in compound related with altered metabolome and microbiota. We hope to utilize
hyperspectral imagingthis spectrum technology to reveal the possible clues of neoplasm for
early stage detection
Material and Methods This research intended to enroll one hundred patients into the study.
This includes patients with positive stool or urine analysis admitted for workup of
colorectal cancer. We will scan the stool and urine with hyperspectral imaging sensoroptical
spectrometer, which utilize multichannel charge-coupled device and InGaAs array to analyze
the full spectrum of light patterns. The image pattern will be stored and used to linked
final diagnosis. Absorption, scattering, and reflection spectra are expected for analysis.
Follow up analysis after cancer staging will be used for lowering background noise in all
spectra.
Expected Results We expect that there will be specific spectral pattern in stool of
colorectal cancer patients, which may be related with cancer staging and different from those
in patients without malignancy. Difference in spectra will lead to discovery of new biomarker
for colorectal cancer and related diseases. The optic spectra pattern of stool and urine may
assist early diagnosis and staging of different malignancies
| Status | Recruiting |
| Enrollment | 100 |
| Est. completion date | September 30, 2018 |
| Est. primary completion date | August 1, 2018 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 20 Years and older |
| Eligibility |
Inclusion Criteria: - patients with positive stool or urine analysis - above 20 year-old - previous stool or urine analysis negative 8 weeks ago Exclusion Criteria: - pregnancy - active gastrointestinal disease one year ago - active infection - having surgery within a year - underlying active gastrointestinal, urinary tract, and coagulation disease |
| Country | Name | City | State |
|---|---|---|---|
| Taiwan | Dong-Ru Ho | Chiayi City |
| Lead Sponsor | Collaborator |
|---|---|
| Chang Gung Memorial Hospital |
Taiwan,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | neoplasm diagnosis | pathology diagnosis in examination | 6 months after examination |