antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response Clinical Trial
Official title:
Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response
Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
Serum AMH has shown to have a high predictive capability of the ovarian response to
stimulation for IVF. On the other hand, patients who are carriers of polymorphisms in the FSH
and LH receptors, have shown to need higher doses of gonadotrophins for ovarian stimulation.
The proportion of carriers has been described to be around 20% of the population.
Nevertheless, the determination of these polymorphisms is not performed in routine practice.
It is unknown if their presence affects to the relationship between serum AMH levels and
ovarian response.
This is a prospective, single center, non-interventional, cohorts study.
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