Retreatment With Epidermal Growth Factor Receptor(EGFR) Tyrosine Kinase Inhibitor in EGFR Mutation Positive Patients

EGFR Positive Non-small Cell Lung Cancer Clinical Trial

Official title:

Retreatment With 1st Generation EGFR TKIs in Sensitizing EGFR Mutation Positive Non-Squamous Cell Carcinoma Patients Who Previously Treated With EGFR TKI and Cytotoxic Chemotherapy

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03382795
• Other study ID #: MLCSG2017001
• Status: Active, not recruiting
• Phase: Phase 2
• Start date: January 3, 2018
• Est. completion date: March 31, 2023

Study information

• Verified date: July 2021
• Source: Korea University Guro Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this trial, treatment efficacy and safety of retreatment with 1st generation epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI)s(Gefitinib/Erlotinib), will be assessed in patients with sensitizing EGFR mutation positive Non-Squamous Cell Carcinoma patients who previously treated with EGFR TKI and cytotoxic chemotherapy

Description:

This study is designed to be multi-center, open-label, single-arm, prospective, phase II trial of patient with sensitizing EGFR mutation positive Non-Squamous Cell Carcinoma patients who previously treated with EGFR TKI and cytotoxic chemotherapy. Approximately 69 patients will be enrolled into the trial, and expected study duration is 48 months from Institutional Review Board(IRB) and Korea Ministry of Food and Drug Safety(MFDS) approval date. The study drug will be administered orally as one tablet(Gefitinib 250mg/ Erlotinib 150mg) once a day until disease progression or manifestation of unacceptable toxicity. The initial dose of the study drug daily can be reduced according to dose reduction criteria in protocol. A cycle of study treatment is defined as 28 days, and subjects will visit the site every 2 cycles(56 days).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 63
• Est. completion date: March 31, 2023
• Est. primary completion date: March 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

1. Males or females = 19 years of age

2. Non Small Cell Lung Cancer(Non-Squamous Cell Carcinoma) patients who had shown clinical benefits (Complete response(CR) or Partial response(PR) or Stable disease(SD) =6 months) from EGFR-TKIs as first line treatment and developed progressive disease, and then received cytotoxic chemotherapy more than 4 cycles and developed progressive disease, and then confirmed T790 negative and sensitizing EGFR mutation(E19Del, L858R, L861Q, G719X, E19insertion) positive in Histologic, cytologic specimen or blood.

3. Patient with at least one measurable lesions according to RECIST v 1.1

4. Expected life expectancy = 12 weeks

5. Eastern Cooperative Oncology Group(ECOG) performance status = 2

6. Patients who have proper hematologic, renal and hepatic functions as follows:

• Absolute neutrophil count(ANC) = 1,500/mm³
• platelets = 100,000/mm³
• Hemoglobin = 9g/dL
• Total bilirubin = 1.25 X UNL
• Aspartate aminotransferase(AST or SGOT) and alanine aminotransferase(ALT or SGPT) = 3.0 X UNL (if liver metastasis =5.0 X UNL)
• Alkaline phosphatase = 2.5 X UNL (if liver metastasis =5.0 X UNL)
• Serum creatinine = 1.5mg/dL

7. patients who are willing to comply with study procedure and voluntarily provide informed consent with signature

Exclusion Criteria:

1. Patients who have preexisting or coexisting malignancies in other parts except for effectively treated non-melanoma skin cancer, cervical carcinoma in situ(CIS) cervical cancer within the last 5 years

2. Patients with brain metastasis except for the followings:

• Asymptomatic and stable brain metastases for which local treatment has been given:

corticosteroids treatment isn't requiured for at least 2 weeks before starting the study treatment.

3. Patients currently receiving palliative radiation therapy or have toxicities from radiation therapy at screening.

4. Patients with clinically active history of interstitial lung disease(ILD), Drug induced ILD, Radiation pneumonitis

5. Patients with clinically significant cardiovascular disease or myocardial infarction within the past 12 months.

6. Patients with active infection or severe systemic disease that are difficult to include in this study

7. Patients who received radiation therapy to target lesion of this study.

8. Patients who had major operation within 4 weeks before starting the study treatment and were not fully recovered.

9. Patients who were administered other study drugs within 4 weeks before starting the study treatment

10. Males and females of reproductive potential who are not using an effective method of birth control and females who are pregnant or breastfeeding or have a positive pregnancy test prior to study entry

11. Patients who are difficult to include in this study in accordance with the investigator's judgment

12. Patients with histories of hypersensitivity to investigational product(IP) or any components of the agent

13. Patients with any of the following genetic predispositions including galactose intolerance, Lapp lactase deficiency, lactose intolerance or glucose-galactose malabsorption

14. Patient previously received cytotoxic chemotherapy within 2 weeks of IP administration

15. Patient received Immunotherapy prior to the study participation

16. Patients who are difficult to include in this study in accordance with the investigator's judgment due to severe adverse effects during previous EGFR TKI treatment

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• EGFR Positive Non-small Cell Lung Cancer

Intervention

Drug:
• EGFR
Gefitinib 250mg or Erlotinib 150mg medication, Once-Daily.

Locations

Country	Name	City	State
Korea, Republic of	Hallym University Sacred Heart Hospital	Anyang	Gyeonggi-do
Korea, Republic of	Chungnam National University Hospital	Daejeon
Korea, Republic of	Chonnam National University Hwasun Hospital	Hwasun	Jeollanam-do
Korea, Republic of	Asan Medical Center	Seoul
Korea, Republic of	Konkuk University Medical Center	Seoul
Korea, Republic of	Korea University Guro Hospital	Seoul
Korea, Republic of	Yonsei University Severance Hospital	Seoul
Korea, Republic of	Pusan National University Yangsan Hospital	Yangsan	Gyeongsangnam-do

Sponsors (2)

Lead Sponsor	Collaborator
Korea University Guro Hospital	Chong Kun Dang Pharmaceutical Corp.

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (18)

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* Note: There are 18 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Objective Response Rate(ORR) including rage of CR&PR	Assessed on based of RECIST 1.1.	Through study completion (5 years)
Secondary	Progression Free Survival, PFS	Progression-free survival (PFS) the time from first dose of the study drug until the date of disease progression or death by any cause	Through study completion (5 years)
Secondary	Overall Survival	Overall Survival (OR) the time from first dose of the study drug until the date of death by any cause	Through study completion (5 years)
Secondary	The incidence of Adverse Events(including Serious Adverse Events and Adverse Drug Reactions)	Assessment on the base of NCI-CTCAE (version 4.03)	Through study completion (5 years)

External Links

•   GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. All cancers (excluding nonmelanoma skin cancer) estimated incidence, mortality and prevalence worldwide in 2012 [Internet]. Geneva: World Health Organization
•   National Comprehensive Cancer Network: National Comprehensive Cancer Network(NCCN) Clinical Practice Guidelines in Oncology- Non-Small Cell Lung Cancer, Version 5.2017.