A Phase II Trial of Cisplatin-Docetaxel Induction Plus Concurrent 3-D Conformal Radiotherapy and Weekly Chemotherapy

Locally Advanced Non-small Cell Lung Cancer Clinical Trial

— TAXCIS  

Official title:

Cisplatin-Docetaxel Induction Plus Concurrent 3-D Conformal Radiotherapy and Weekly Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer Patients: A Phase II Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03371550
• Other study ID #: 2004/07
• Status: Completed
• Phase: Phase 2
• First received: November 30, 2017
• Last updated: December 12, 2017
• Start date: August 5, 2004
• Est. completion date: October 31, 2011

Study information

• Verified date: November 2017
• Source: Centre Antoine Lacassagne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Concurrent chemoradiotherapy (CHRT) is the standard of care for unresectable locally advanced stage III non-small cell lung cancer. However, the optimal combination remains unclear. The aim of this study is to evaluate the efficacy of 2 induction chemotherapy cycles (days 1 and 22) with docetaxel 75 mg/m2 and cisplatin 75 mg/m2 followed by concurrent chemotherapy (weekly docetaxel-cisplatin, 20 mg/m2) and 3-D conformal radiotherapy for 6 weeks (66 Gy/5 fractions per week/2 Gy per fraction). ). The primary endpoint is the response rate. Secondary objectives are toxicity, time to progression, and overall survival.

Description:

Lung cancer is the most common malignancy among men in most countries and constitutes the leading cause of cancer death worldwide. Non-small cell histology represents roughly 80% of lung cancer cases comprising one third of patients with stage III, locally-advanced disease at diagnosis. Some stage IIIA cancers are considered resectable but many stage IIIA (with bulky N2) and stage IIIB (T4 any N M0, any T N3M0) cancers are considered unsuitable for surgery. However, some authors have shown that surgery after chemoradiotherapy (CHRT) is beneficial for at least progression-free survival (PFS). Since the 90s, CHRT has become the cornerstone of inoperable locally advanced non-small cell lung cancer (NSCLC). A meta-analysis of 52 randomized studies showed a survival improvement of 3% at 2 years and 2% at 5 years for patients treated with CHRT versus radiotherapy alone [6]. Concomitant chemoradiation was demonstrated to be better than sequential administration in terms of overall survival (OS) in 3 out of 4 randomized studies with esophagitis as the dose-limiting toxicity. Nevertheless, the median survival was around 16 months and improvement is needed. To better control micrometastatic disease and reduce distant relapses, one possibility is to increase radiosensitization with higher doses of chemotherapy.The aim of this phase II study is to evaluate the anti-tumoral activity of a weekly docetaxel-cisplatin combination administered concurrently with radiotherapy after 2 induction cycles with the same drugs.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: October 31, 2011
• Est. primary completion date: October 31, 2010
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• histologically or cytologically confirmed NSCLC,

• stage IIIB (excluding malignant pleural or pericardial effusions, tumoral volume exceeding one radiation field,

• N3 supraclavicular, and contralateral hilar nodal involvement) or inoperable stage IIIA defined by the new International Staging System [21],

• 18 = age = 75 years,

• Eastern Cooperative Oncology Group Performance Status (ECOG PS) =2,

• weight loss <10%,

• at least one measurable lesion according to RECIST 1.0 criteria,

• adequate hematopoietic function (absolute neutrophil count =2 × 109/l, platelets =100 × 109/l, and hemoglobin level =10g/dl), adequate hepatic function [total serum bilirubin less than or equal to the institutional upper limit of normal (ULN), aspartate aminotransferase =1.5× ULN, and alkaline phosphatase =5× ULN], and adequate renal function (serum creatinine =1.5× ULN).

Exclusion Criteria:

• patients previously treated with radiotherapy or chemotherapy for NSCLC,

• previous cancer except basocellular carcinoma and in situ carcinoma of the cervix curatively treated and other cancers curatively treated for at least 5 years,

• peripheral neuropathy NCI-CTC grade =2,

• noncontroled severe disease,

• pregnant or breast-feeding women.

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Locally Advanced Non-small Cell Lung Cancer
• Lung Neoplasms

Intervention

Drug:
• Docetaxel
Induction chemotherapy

Radiation:
• concomitant radiotherapy
Pulmonary and mediastinal radiotherapy

Drug:
• Cisplatin
Induction chemotherapy

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Centre Antoine Lacassagne

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To evaluate the antitumor activity of Docetaxel - Cisplatin and concomitant thoracic radiotherapy after Docetaxel - Cisplatin induction chemotherapy in patients with locally advanced non-operable NSCLC by tumor response rate	Tumor Response rate between 6 and 8 weeks according to RECIST 1.0 criteria after the end of radiotherapy (except in the case of early progression) that patients: having received at least 4 weekly injections of Docetaxel and Cisplatin,; who have received the full radiotherapy treatment (except in case of cessation for toxicity, in which case the patients will be evaluable).	up to 3 years
Secondary	Overall survival and at 12 months	To evaluate the overall survival at 12 months between the first day of treatment to the death	up to 3 years
Secondary	Response delay	Complete response delay evaluated between the day of the complete response to the progression and partial response between the first day of the treatment and the progression	up to 3 years
Secondary	Progression Free Survival	To evaluate Progression free survival according to RECIST criteria	up to 3 years
Secondary	Tolerance profile of the association in terms of immediate and delayed toxicity	To evaluate early and late toxicity according to the NCI-CTC	up to 3 years
Secondary	Quality of Life evaluation (EORTC QLQ-C30 and QLQ-LC13)	To evaluate the quality of life at inclusion, at the end oh chemotherapy, 2 months after the radiotherapy and every 3 months until end of study	up to 3 years