Metabolic and Functional Impact of Various Breakfast Models

Metabolism and Nutrition Disorder Clinical Trial

Official title:

Metabolic Responses of a Single Bout of Low-intensity Exercise Following Mixed Meals in Healthy Individuals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03240757
• Other study ID #: Colazioni/1
• Status: Completed
• Phase: N/A
• First received: August 1, 2017
• Last updated: August 4, 2017
• Start date: July 14, 2009
• Est. completion date: May 28, 2010

Study information

• Verified date: August 2017
• Source: Ospedale San Donato
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In the present study the investigators compared the hormonal and metabolic effects of three meal loads very popular among Italian eating habits, both in the resting- and exercising state. Given the lack of time is considered a common barrier to exercise adherence, we wanted to identify a low dose of exercise capable to produce health benefits in the post-absorptive status elicited by three commonly consumed meal-models in Mediterranean countries. To this end, healthy young volunteers firstly underwent an oral glucose tolerance test (OGTT) and three meal tolerance tests. Secondly, in an extra set of experiments, subjects cycled at low intensity for the last 20 minutes of the same glucose/meal tolerance test. Glycemia, insulinemia, ghrelinemia, lipidemia, and satiety were measured throughout OGTT and each test-meal load.

Description:

The investigators evaluated postprandial responses (glucose, insulin, ghrelin, free fatty acids (FFA)) elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise were investigated. All subjects underwent a 50-g OGTT (A) and 3 test-meal loads: milk and cereals (B1); milk, apple and chocolate cream-filled sponge cake (B2); milk, bread, apple and hazelnut chocolate cream (B3). In the exercise trial, participants cycled for 20 minutes at 40% VO2max, 100 minutes after load ingestion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: May 28, 2010
• Est. primary completion date: May 28, 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• age between 18 and 40 years

• normal body weight (BMI =18.5 - 24.9 according to NHLBI)

• stable diet

Exclusion Criteria:

• Diabetes, tipe 1 and 2 (ADA criteria)

• Glucose intolerance (ADA criteria)

• Dyslipidemia (ATP III according to NCEP)

• Metabolic syndrome

Related Conditions & MeSH terms

• Metabolism and Nutrition Disorder
• Nutrition Disorders

Intervention

Dietary Supplement:
• Breakfast
All subjects received a standard 75-g OGTT to assess eligibility for the study. The 19 subjects matching the inclusion criteria completed 2 experimental trials: resting and exercise. During the resting trial, all subjects underwent an OGTT (50-g: A) and 3 meal tolerance tests [one for each breakfast tested: B1 = milk (125ml) and cereals (30g); B2 = milk (220ml), apple (200g) and chocolate cream-filled sponge cake (30g); B3 = milk (125ml), apple (150g), bread (50g) and hazelnut chocolate cream (15g)]. In the exercise trial, 100 minutes after the glucose/meal ingestion, participants cycled for 20 min at 40% of maximum oxygen uptake.

Other:
• exercise
aerobic exercise at 40% of VO2max, for 20 minutes

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Ospedale San Donato	University of Milan

References & Publications (1)

R Codella, A Caumo, S Benedini, M Adamo, A Ferrulli, C Macrì, I Terruzzi, L Luzi. Metabolic responses of a single bout of low-intensity exercise following mixed meals in healthy individuals. ADA (American Diabetes Association) 77th Scientific Session, 8-1

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma glucose responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.	Postprandial glycemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.	The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Primary	Plasma insulin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.	Postprandial insulinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.	The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Primary	Plasma ghrelin responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.	Postprandial ghrelinemic responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.	The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).
Primary	Plasma free fatty acids (FFA) responses of a single bout of low-intensity exercise following mixed meals in healthy individuals.	Postprandial plasma FFA responses elicited by three diverse test-meal loads followed by a 20-min bout of low-intensity aerobic exercise.	The entire study lasted for 9 experimental days (1 day for eligibility, 4 days for resting trial, 4 days for exercise trial).