Functional Magnetic Resonance Imaging Clinical Trial
Official title:
Open Label Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Clinical Practice
The purpose of this research study is to evaluate the feasibility in conducting advanced MRI sequences in a clinical setting. The study will be observational in nature, and will only evaluate the studies of patients that have already been prescribed an advanced MRI for clinical neurological purposes. The only difference for the subject in participating in this study is that the data and information about their scan can be used and disclosed for research purposes, which is understanding if the time of the scan, patient comfort, and quality of the data are feasible. Standard MRI's have been extremely beneficial in the diagnosis and assessment of disease, injury, and anomalies throughout the body. Adding advanced MRI sequences to the arsenal of current standard MRI sequences, as well as analyzing the clinical significance of the data, may improve the benefits of MRI in the future. Within this scope, the study will be looking at the following factors: 1. The total time of the scan, including: - Patient arrival time/lateness - Patient preparation time - Time scanner is being occupied - Patient compliance (is the patient continually stopping the study for breaks, fear, movement, etc) 2. Patient dropout rate, including: - Change of mind - Cost of study is too much - Failure to finish the scan 3. Usability of data, including: - Movement artifact - Patient requiring re-scan for any reason The scan will consist of several advanced MRI sequences that will average between 7-15 minutes each, in addition to a routine 5 minute standard MRI sequence. The variability in the number of advanced sequences depends on the prescription and patient history. All sequences are performed using an FDA-approved MRI scanner.
An MPRAGE is a high quality anatomical image of the brain. This is used as an anatomical overlay, so that all data collected from the advanced sequences below can be correlated with the correct brain areas in three dimensional space. 1. Resting BOLD - BOLD stands for blood oxygen level dependent. This functional sequence allows for the viewing of the thinking brain at rest, and looks at brain areas that are functionally working together at the same time. The brain is in one of its most active states when it is at rest, and literature has shown that a few neurological illnesses such as OCD, depression, and pain have been associated with analyzing the data in this sequence. 2. Arterial Spin Labeling (ASL) - ASL tracks the blood flow in the brain visually and gives a statistical value of how much blood is in each region in cc's per 100 grams of brain per second. 3. Diffusion Tensor Imaging (DTI) - DTI tractography shows the different fiber tracts in the brain using a 3D model. Fiber tracts are the physical neural pathways that can show disruption or connection in communication between different areas of the brain. This is an effective technique when looking at traumatic brain injury. 4. Magnetic Resonance Spectroscopy (MRS) - MRS measures the ratios of select chemical compounds in the brain in relation to each other. This has shown to be effective in analyzing memory loss, dementia, and Alzheimer's type disorders. 5. Stimulated BOLD - The same sequence as the resting BOLD, except the brain is being scanned during the completion of a task, instead of rest. By specifying the task (visual, problem solving, language, etc), the different areas of the brain working together to complete this task can be imaged. This is very effective for task specific symptoms and deficits. The methods and procedures in this study are all under the observational category. MRI's are FDA approved and are non-experimental devices. The goal of this research is to assess the feasibility of the scan itself, so everything done with respect to the scan is considered observational in nature. If the subject drops out of the study, anything described in this protocol will still be able available to the subject as standard medical care. The observational procedures will involve recording data for the advanced MRI scans, and no information will be shared for research if the subject does not sign the consent form. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03988829 -
Strategic Training to Optimize Neurocognitive Functions in Older Adults
|
N/A | |
Recruiting |
NCT03210428 -
Quantitative MR Imaging in Locally Advanced Cervical Cancer
|
||
Recruiting |
NCT05575583 -
rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction
|
N/A | |
Completed |
NCT01244282 -
A Study of Two Methodologies for Measuring Blood Flow in the Brain in Response to Non-Drug Stimuli (P08085/MK-0000-180)
|
Phase 1 | |
Completed |
NCT03868358 -
Effect of Intermittent Theta Burst Stimulation (iTBS) for Alleviating Symptoms of Schizophrenia Patients
|
N/A | |
Completed |
NCT02863094 -
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Schizophrenia Patients With Auditory Hallucinations
|
N/A | |
Recruiting |
NCT05502822 -
High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia
|
N/A | |
Recruiting |
NCT05221632 -
Accelerated Continue Theta-burst Stimulation (acTBS)Treatment for Obsessive Compulsive Disease
|
N/A | |
Not yet recruiting |
NCT06376500 -
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
|
N/A | |
Recruiting |
NCT04599764 -
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease
|
N/A | |
Completed |
NCT03946839 -
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
|
||
Completed |
NCT02969941 -
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Parkinson Disease
|
N/A | |
Recruiting |
NCT03262753 -
Long-term Outcomes and Vascular Evaluation After Coarctation of the Aorta Treatment
|
N/A | |
Recruiting |
NCT05440292 -
Effects of Individualized Accurate Positioning TMS Based on Task fMRI Activation on Upper Extremity Function After Stroke
|
N/A | |
Completed |
NCT03472703 -
Effect of Consumption on Cognitive Processes
|
N/A | |
Recruiting |
NCT05194254 -
MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD
|
N/A | |
Not yet recruiting |
NCT06027190 -
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
|
N/A | |
Recruiting |
NCT05286645 -
Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Depressive Disorder
|
N/A | |
Completed |
NCT03965338 -
Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study
|
N/A | |
Recruiting |
NCT03991572 -
rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network Mechanism
|
N/A |