Effect of Laryngoscopy and Tracheal Intubation Clinical Trial
Official title:
Oral Amantadine Versus Gabapentin to Attenuate the Hemodynamic Response to Laryngoscopy and Tracheal Intubation and Their Effect on β-endorphin
To evaluate the effect of oral amantadine versus gabapentin premedication on the hemodynamic response to laryngoscopy and tracheal intubation and their effect on β-endorphins.
Direct laryngoscopy and passage of endotracheal tube through the larynx is a noxious
stimulus, which can provoke untoward response in the cardiovascular, respiratory and other
physiological systems. Gabapentin, is 1-aminomethyl cyclohexane acetic acid.Gabapentin is
structurally related to the neurotransmitter gamma-aminobutyric acid (GABA). Gabapentin act
in central nervous system CNS), it acts by decreasing the synthesis of neurotransmitter
glutamate and by binding to the alpha 2 delta subunits of voltage dependent calcium channels.
Amantadine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, and compared
to ketamine, it is well tolerated with fewer side effects (mainly dizziness, sedation, and
dry mouth). Amantadine's formulation permits the oral route for drug delivery, as well as the
IV route. The side-effects profile of amantadine via all routes seems not to be harmful in
appropriate dosages.. Amantadine has been clinically used as an antiviral drug, for dementia,
and in the treatment of Parkinson's disease and spasticity. It is a non-competitive NMDA
receptor antagonist, and compared to ketamine, it is well tolerated with fewer side effects
(mainly dizziness, sedation, and dry mouth). Amantadine's formulation permits the oral route
for drug delivery, as well as the IV route. The side-effects profile of amantadine via all
routes seems not to be harmful in appropriate dosages.
In the central nervous system, beta-endorphins bind mu-opioid receptors and exert their
primary action at presynaptic nerve terminals. However, instead of inhibiting substance P,
they exert their analgesic effect by inhibiting the release of GABA, an inhibitory
neurotransmitter, resulting in excess production of dopamine.
The investigators designed this study to prove the efficacy of oral amantadine versus
gabapentin premedication on the hemodynamic response to laryngoscopy and tracheal intubation
and their effect on β-endorphins.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03456947 -
Pregabalin Stabilize Cardiovascular Response to Intubation
|
Phase 4 |