Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT03154398 |
| Other study ID # |
Assiut1991 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
May 1, 2017 |
| Est. completion date |
December 1, 2019 |
Study information
| Verified date |
February 2021 |
| Source |
Assiut University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Diabetes Mellitus is the most common disorder seen. The impact of this disease on the quality
of life, and on morbidity and mortality through the complications that affect the small and
large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic heart disease
has been emphasized by the findings of the national commission (USA) on diabetes .
So, there was curiosity to understand and learn the association of this disorder with another
common endocrine gland function that is thyroid gland . The association between these two
disorders has long been recognized although the prevalence of thyroid dysfunction in diabetic
population varies widely between studies. With insulin and thyroid hormone being intimately
involved in cellular metabolism and thus excess or deficit of these hormones result in
functional derangement of the other .
Diabetic patients have higher prevalence of thyroid disorder when compared with the normal
population. Diabetic women are more frequently affected than men and hypothyroidism is more
common than thyrotoxicosis.
As Hyperthyroidism impairs glycemic control in diabetic subjects, while hypothyroidism may
increase susceptibility to hypoglycemia thus complicating diabetes management so Severe
diabetic complications where noted in patients with sub- clinical hypothyroidism .
Sub-clinical hypothyroidism is an independent risk factor for development of diabetic
nephropathy.
Description:
Recognition and treatment of thyroid dysfunction in diabetic patients will benefit glycemic
control and improve general well-being Diabetic nephropathy, a major microvascular
complication of type 2 diabetes mellitus, is an important cause of chronic kidney disease. It
results from interactions between hemodynamic and metabolic factors.
