POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Postoperative Cognitive Dysfunction Clinical Trial

Official title:

Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03084393
• Other study ID #: XYFY2017-KL004-01
• Status: Completed
• Start date: March 1, 2017
• Est. completion date: April 30, 2018

Study information

• Verified date: March 2020
• Source: Xuzhou Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 215
• Est. completion date: April 30, 2018
• Est. primary completion date: April 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

• Non-cardiac surgery patients;

• Age is greater than or equal to 60 years old;

• Han Nationality, mother tongue is chinese;

• The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

• The Geriatric Depression Scale (GDS) grade 1 or 2;

• The important function without serious heart, brain, liver, kidney, lung and other organs;

• The ASA class I or II;

• The people signed informed consent.

Exclusion Criteria:

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.;

• Had severe head and face disease, trauma history or history of surgery;

• The serious body disease and tobacco, wine and other substance abuse history;

• The presence of malignant tumor with shorter survival disease.

Related Conditions & MeSH terms

• Cognitive Dysfunction
• Postoperative Cognitive Dysfunction

Locations

Country	Name	City	State
China	Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University	Xuzhou	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Xuzhou Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the neuropsychological tests	the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement Test,the Finger Tapping Test, the Word Fluency Test and the Building Block Test.	1 day before surgery(baseline)
Primary	Mini-Mental score examination [MMSE]	Mini-Mental score examination [MMSE] used for screening of dementia	1 day before surgery(baseline)
Primary	the neuropsychological tests	the neuropsychological tests to measure cognitive function, including the Trail Making Test, the Grooved Pegboard Test, the Digit Span Test, the Number-Symbol Replacement,the Test Finger Tapping Test, the Word Fluency Test and the Building Block Test.	within the first 7 days (plus or minus 2 days) after surgery
Primary	Mini-Mental score examination [MMSE]	Mini-Mental score examination [MMSE] used for screening of dementia	within the first 7 days (plus or minus 2 days) after surgery