Barrett's Esophagus With Dysplasia Clinical Trial
Official title:
Prospective Characterization of the Neo-squamous Epithelial Barrier Following Successful Endoscopic Therapy in Barrett's Esophagus
To prospectively assess the functional aspects of the the esophageal squamous epithelial barrier and correlate this with tissue inflammation and intercellular space dilation in patients who have successfully completed endoscopic radiofrequency ablation versus balloon cryotherapy for Barrett's Esophagus related metaplasia.
The investigators will measure and correlate mucosal impedance (measured using a novel endoscopic mucosal impedance catheter), intercellular space as measured with transmission electron microscopy and tissue levels of prostaglandin E2 in patients undergoing surveillance following successful endoscopic therapy (defined as two negative endoscopic surveillance histology for intestinal metaplasia). Mucosal impedance will be measured by an endoscopic probe. Research biopsies will also be obtained for measurement of tissue levels of prostaglandin E2 and intracellular space with transmission electron microscopy. Volumetric laser endomicroscopy will measure the precise thickness of and area of subsquamous structures underneath the neosquamous epithelium. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03814824 -
Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)
|
N/A | |
| Recruiting |
NCT03364114 -
Endorotor Resection In Refractory Barrett's Dysplasia Patients
|
N/A |