Postoperative Cognitive Dysfunction Clinical Trial
Official title:
Correlations of Epigenetic Changes With POCD in Surgical Patients
Postoperative cognitive dysfunction (POCD) is a subtle cognitive dysfunction, especially postoperative memory impairment lasting for weeks or months. The underlying pathophysiological mechanism of POCD remain unclear. The aim of this study is to explore the epigenetic changes during perioperative period and its correlation with POCD in surgical patients.
The incidence of postoperative cognitive dysfunction (POCD) in elderly patients ranges
widely from 16% to 21% and is associated with adverse outcomes. The exact cause of POCD
remains unknown. Extensive studies report that epigenetic modification, including the
alteration of DNA methylation and chromatin structure, plays an important part in the
regulation of memory and learning. The present study thus hypothesize that epigenetic
modification may increase the risk for POCD. The present study will enrolled the elderly
patients (agedā„65) and young and middle-aged patents (aged 20-50) who are planning to
undergo elective noncardiac surgery under general anesthesia. Perioperative clinical
characteristics of all patients will be recorded. Participants enrolled will be evaluated
for POCD with Mini-Mental State Examination (MMSE) on preoperative day, postoperative days
1. Postoperative pain will be evaluated by the numerical rating scale (NRS). The patients'
blood will be collected in the morning on the day before surgery and after surgery when they
recover consciousness for the detection of concentration of 5-methylcytosine (5mC) and
5-hydroxymethylcytosine (5hmC) by enzyme-linked immunosorbent assays (ELISA).
The present study may help to find whether epigenetic changes will occur after surgical and
anesthesia stress and will be an important factor for POCD in elderly patients.
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Observational Model: Case Control, Time Perspective: Prospective
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