Acute Kidney Injury With Cirrhosis Clinical Trial
Official title:
On Demand Versus Protocol-guided Renal Replacement Therapy for Management of Stage 3 Acute Kidney Injury in Patients With Cirrhosis -A Prospective Randomized Controlled Trial
Intervention: All patients at presentation would be assessed for the underlying cause of and
will be managed by removal of all precipitants(careful review of medications, diuretics,
nephrotoxic drugs,vasodilators or non-steroidal anti-inflammatory drugs). The second step
would be to consider plasma volume expansion in patients with hypovolemia (the choice of
fluid could either be a crystalloid or albumin or even blood as indicated) along with
identification and early treatment of bacterial infections. Along with this patients with a
differential diagnosis of HRS-AKI would be given terlipressin ( or noradrenaline/octreotide
midodrine in case of contraindication to terlipressin). Patients with a clinical diagnosis of
ATN would be randomized to the on-demand versus protocol-guided dialysis groups. Further,
patients with urine output of less than 0.5ml/kg/hour for 4-6 hours despite adequate fluid
resuscitation and vasoconstrictors would also be subjected to randomization.
1. In the on-demand group patients would get dialysis only when patient fulfills absolute
criteria requiring dialysis such as metabolic acidosis with ph<7.2, hyperkalemia,
refractory fluid overload (non-responsive to diuretics) or oliguria with urine output of
less than 0.5ml/kg for more than 24-48 hours from the time of randomization
2. In the protocol guided group patients all patients would be considered for dialysis
within 6 hours of randomization After randomization patients would receive dialysis as
three sessions per week of at least 4 h with a blood flow >200 mL/min and a dialysate
flow >500 mL/min in intermittent group and as 20-25 mL/kg/h of effluent, by filtration
and/or diffusion in continuous form until recovery of renal functions
n/a