The Pathophysiology of Functional Neurological Disorders

Functional Neurological Disorders Clinical Trial

Official title:

The Pathophysiology of Functional Neurological Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02905877
• Other study ID #: 16/0275
• Status: Completed
• Start date: September 2016
• Est. completion date: September 30, 2019

Study information

• Verified date: March 2020
• Source: University College, London
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Functional disorders, also called psychogenic or psychosomatic are very common, disabling and their costs to society are immense.

Functional movement disorders are abnormal, involuntary movements, that are illogical in terms of classic neurology. Intriguingly, they typically manifest when patients pay attention to them and disappear with distraction.

The investigators aim to further the understanding of the pathophysiological mechanisms underlying functional neurological disorders in order to improve treatment. In particular they aim to understand the effect of attention on movement in general, on functional neurological mechanisms and on the sense of agency (of subjective control) over a movement.

Patients with a functional neurological disorder, patients with an organic neurological disorder and healthy participants will perform simple tasks, such as reaching to a target, while additional tasks will manipulate their attention. The effects of these attentional manipulations will be analysed on several levels: movement performance, analysed by the kinematics and electromyography (EMG),and psychophysical measures, such as the sense of agency.

If the hypothesis turns out to be true, then changing the attentional focus could be used as a treatment in functional neurological disorders.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 130
• Est. completion date: September 30, 2019
• Est. primary completion date: September 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• We will recruit three groups of participants:

1. functional neurological disorders, e.g. functional tremor: diagnosed by a neurologist.

2. organic counterpart of the functional neurological disorders, e.g. in the case of functional tremor, the organic counterpart would be organic tremor: presence of an organic tremor according to internationally recognised guidelines and diagnosed by a neurologist.

3. healthy age-matched controls.

Exclusion Criteria

• Healthy Participants: Major neurological disorder.

All groups:

1. Age under 18 or over 80

2. Significant impairment in ability to give informed consent for study procedures due to significant cognitive impairment and/or inability to understand study literature,

3. very severe tremor

4. moderate or severe cognitive impairment

Related Conditions & MeSH terms

• Conversion Disorder
• Functional Neurological Disorders
• Nervous System Diseases

Intervention

Other:
• Behavioural study
reaching studies and other behavioural studies.

Locations

Country	Name	City	State
United Kingdom	Institute of Neurology, University College London	London

Sponsors (1)

Lead Sponsor	Collaborator
University College, London

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Tremor severity, assessed by kinematics, under different attentional conditions		1 year
Secondary	Sense of agency, assessed by intentional binding, under different attentional conditions		1 year