Transpulmonary Pressure and Airway Pressure Release Ventilation (APRV).

Patient Mechanically Ventilated With APRV Mode Clinical Trial

Official title:

Incidence of High Levels of Transpulmonary Pressure During the Use of Airway Pressure Release Ventilation.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02866513
• Other study ID #: 2015-19
• Status: Completed
• Phase: N/A
• First received: August 2, 2016
• Last updated: November 13, 2017
• Start date: February 2016
• Est. completion date: March 2017

Study information

• Verified date: August 2016
• Source: Assistance Publique Hopitaux De Marseille
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.

The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: March 2017
• Est. primary completion date: December 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult

• Patient mechanically ventilated for more than 48 H for acute respiratory failure

• Decision to use of the APRV mode by clinicians in charge of the patient

Exclusion Criteria:

• Contraindication for the use of a nasogastric tube

Related Conditions & MeSH terms

• Patient Mechanically Ventilated With APRV Mode

Intervention

Other:
• evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.

Locations

Country	Name	City	State
France	Assistance Publique Hôpitaux de Marseille hôpital de la Timone	Marseille

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique Hopitaux De Marseille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Transpulmonary pressure	Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.	24 hours
Secondary	Maximal value of transpulmonary pressure	Value of tidal volume > 8 ml/kg	24 hours