Suspected Infection With Vancomycin Susceptible Bacterial Strains Clinical Trial
Official title:
Pharmacokinetics of Vancomycin in ICU Patients
Vancomycin is frequently under-dosed in ICU patients during the first 24-48 hours of
treatment. Glomerular hyperfiltration syndrome, increased drug volume of distribution,
vasopressor use, male sex and hypoalbuminemia are identified risk factor for vancomycin
underdosing in ICU patients, among others.
To date, bedside estimation of vancomycin volume of distribution is challenging, and new
methods for optimizing drug administration are required.
The Picco device is a moderately invasive hemodynamic monitoring system, providing
parameters that may help estimation of vancomycin pharmacokinetics parameter.
The aim of this study is to test whether addition of hemodynamic parameters would improve
pharmacokinetics modelling of vancomycin concentration in ICU patients.
n/a
Observational Model: Case-Only, Time Perspective: Retrospective