The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Systemic Inflammatory Response Syndrome Clinical Trial

Official title:

The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT02820090
• Other study ID #: 15210511726
• Status: Active, not recruiting
• Phase: N/A
• First received: May 31, 2016
• Last updated: June 29, 2016
• Start date: May 2014
• Est. completion date: April 2017

Study information

• Verified date: June 2016
• Source: Beijing Chao Yang Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Description:

In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 300
• Est. completion date: April 2017
• Est. primary completion date: April 2017
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 14 Years to 80 Years

Eligibility

Inclusion Criteria:

• oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure

• mechanical ventilation time over than 48 hours

• Glasgow score greater more than or equal to 13 points

Exclusion Criteria:

• Aged less than 14 years or more than 80 years old

• patients with neuromuscular disease

• pure heart failure pulmonary edema patients

• patients with tracheotomy

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Systemic Inflammatory Response Syndrome
• Ventilator Weaning

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Chao Yang Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The relationship between mechanical ventilation of ventilator and inflammatory response	Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related.	January 2014 to December 2016	Yes
Secondary	The relationship between diaphragm movement function and weaning from mechanical ventilation	To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation.	January 2016 to December 2017	Yes
Secondary	the output of CO2		January 2016 to December 2017	Yes