Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.

Endemic and Emerging Diseases in Populations of Homeless Clinical Trial

— SDF  

Official title:

Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02819128
• Other study ID #: 2013-44
• Status: Completed
• Phase: N/A
• Start date: January 25, 2014
• Est. completion date: October 26, 2022

Study information

• Verified date: April 2023
• Source: Assistance Publique Hopitaux De Marseille
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hypothesis:

Homeless people have infections not diagnosed with a potential impact on their health status.

Main Purpose: Improve the etiological diagnosis of endemic and/or emerging pathologies among homeless people.

Description:

In Marseilles, the population of homeless is estimated at 1500 individuals, including 800 usually sleeping in the street, 600 in foster homes and a hundred in the structures of care. The precarious living conditions of homeless persons promote the emergence or re-emergence of many communicable infectious diseases homeless people whose symptoms are often overlooked by the subject and rarely established etiologic diagnosis.

Among these diseases, frequently described in the literature are infestation by lice and infectious diseases that they transmit (Bartonella quintana), skin infections, hepatitis E and C and finally the infection with Tropheryma Whipplei. In this study we propose to systematically in homeless subject an etiological diagnosis of pathogens at the origin of these diseases (i) to improve knowledge (ii) to improve their management, (iii) to limit the contagion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 722
• Est. completion date: October 26, 2022
• Est. primary completion date: September 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Homeless Subject on the day of the study in one of two shelters for homeless Marseille ( Madrague City and Forbin )

• Major subject ( > or equal to 18 years)

• Freely about having signed the written informed consent,

• About affiliated with a social security scheme

Exclusion Criteria:

• Minor Subjects ( < 18 years )

• Major subject under guardianship (L. 1121-8 )

• Subject privated of freedom or under court order (L. 1121-6 )

• Subject refusing to sign the informed consent form ,

• Subject not affiliated with a social security insurance

• Pregnant women , parturient or nursing (L. 1121-7 ) .

Related Conditions & MeSH terms

• Endemic and Emerging Diseases in Populations of Homeless

Intervention

Other:
• Swabs skin, pharyngeal, and blood sample
Collection of one blood sample with a volume of 10 mL (2 tubes of blood 5 mL ) and 2 swabs ( throat and skin ).
• Collection of body lice
For the subjects infested with body lice , if they want, their underwear will be recovered and sent to the laboratory to measure the resistance to permethrin.

Locations

Country	Name	City	State
France	Assistance Publique Hopitaux de Marseille	Marseille

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique Hopitaux De Marseille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of subjects with an established microbiological diagnosis		3 years
Secondary	Prevalence of skin infections		1 day
Secondary	Prevalence of Tropheryma whipplei infections		1 day
Secondary	Prevalence of infestation by body lice		1 day
Secondary	Percentage of body lice resistant to permethrin		1 day
Secondary	Prevalence of infections by Bartonella quintana		1 day
Secondary	Prevalence of infection by hepatitis E and C		1 day