Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02779530

CYP4A11 and CYP4F2 Gene Variants as Makers of Cardiovascular Adverse Events of Non-steroidal Anti-inflammatory Drugs

Drug-Related Side Effects and Adverse Reactions Clinical Trial

Official title:
Evaluation of CYP4A11 and CYP4F2 Gene Variants as Makers in Edema and Elevated Blood Pressure Occurrence After Nonsteroidal Anti-inflammatory (NSAID) Use

Clinical Trial Summary

Randomized, double-blinded, cross-over and placebo controlled clinical trial to evaluate the association between genetic polymorphism of CYP4F2 with cardiovascular adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs). Two groups were included according the CYP4F2 V433M genetic polymorphism (control - MM, N=7 vs. VV or VM variants, N=13). According the sample size planned, a mean difference of total body water delta between groups (control vs. polymorphic) of at least allow 10% could be observed.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Screening

Related Conditions & MeSH terms

  • Drug-Related Side Effects and Adverse Reactions
Clinical Trial Details
NCT number NCT02779530
Study type Interventional
Source University of Sao Paulo
Contact
Status Completed
Phase Phase 4
Start date October 2011
Completion date July 2013
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT03258151 - Association of Genetic Polymorphisms With Docetaxel-based Chemotherapy Toxicities in Chinese Solid Tumor Patients
Recruiting NCT05202964 - Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)
Completed NCT04597593 - Association Between Genetic Variant Scores and DOACs (DARES2)
Recruiting NCT05096338 - Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer
Recruiting NCT05078190 - Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer
Completed NCT02457039 - Acupuncture Prevents Chemobrain in Breast Cancer Patients N/A
Recruiting NCT03047863 - Therapeutic Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors N/A
Recruiting NCT03051880 - Preventive Effect of EGF Cream for Cutaneous Adverse Event of EGFR Inhibitors N/A
Completed NCT02482025 - The Secure Messaging for Medication Reconciliation Tool (SMMRT) Trial N/A
Not yet recruiting NCT03147157 - The Effect of Human Leukocyte Antigen Macthing on Guiding Tacrolimus Regimen After Liver Transplantation N/A
Recruiting NCT03156348 - Impact of Clinical Pharmacist on Adverse Drug Events in Older Adults N/A
Recruiting NCT03501108 - Discontinuation of Long-term Medications in Older People Entering Nursing Home Care N/A
Recruiting NCT06427317 - Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment
Completed NCT03227653 - Neuropsychiatric Side Effects of Efavirenz in Children Living With HIV
Completed NCT03177174 - Different Chemotherapy Protocols Combined With Intensity Modulated Radiation Therapy in Patients With Locally Advanced Nasopharyngeal Carcinoma N/A
Recruiting NCT04077281 - Improving Medication Prescribing-Related Outcomes for Vulnerable Elderly In Transitions N/A
Not yet recruiting NCT05247814 - Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients
Recruiting NCT03938597 - Investigation of Serious Adverse Events Following Vaccination Against Yellow Fever: Emphasis on Genetic Basis and Biological Markers
Recruiting NCT06291688 - Applying Mobile Healthcare Education to Improve Cutaneous Self-care Capability N/A
Active, not recruiting NCT02119078 - Acute Care for Elders (ACE) Program at OHSU Hospital N/A