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Urease Inhibitor Drug Treatment for Urea Cycle Disorders

Ornithine Transcarbamylase Deficiency Clinical Trial

Official title:
Manipulating the Gut Microbiome in Urea Cycle Disorders

Clinical Trial Summary

The purpose of this study is to determine if acetohydroxamic acid (AHA) can prevent hydrolysis of urea by inhibiting the bacterial urease of gut flora of both healthy control adults as well as adults with urea cycle disorders.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02670889
Study type Interventional
Source Children's Research Institute
Contact Nicholas Ah Mew, MD
Phone 202-476-5863
Email NAhMew@childrensnational.org
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date November 2016
Completion date March 2019
View Details
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