Advanced Hepatocellular Carcinoma Clinical Trial
Official title:
A Clinical Study of Adoptive Cellular Immunotherapy Using Pluripotent Killer T Cells Expressing Antibodies for Programmed Death 1 (PD-1) in Treating Patients With Advanced Hepatocellular Carcinoma
Objectives:
The purpose of this study is to evaluate the safety and efficacy of PIK-PD-1 Cells in the
treatment of advanced Hepatocellular Carcinoma.
Methods:
This study designs a novel therapy using PIK-PD-1 cells. 40 patients with advanced
Hepatocellular Carcinoma will be enrolled. They are randomly divided into dendritic
cell-precision multiple antigen T cells (DC-PMAT) group and PIK-PD-1 cells group. Both
DC-PMAT treatment and PIK-PD-1 cells treatment will be performed every 3 weeks with a total
of three periods. The mail clinical indicators are Progression-Free-Survival and Overall
Survival.
A total of 40 patients may be enrolled over a period of 1-2 years. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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