Molecular and Functional Neurobiology of Physical Exercise

Physical Exercise Behavior (Liking/Aversion) Clinical Trial

— EXEBRAIN  

Official title:

Molecular and Functional Neurobiology of Physical Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02615756
• Other study ID #: 19/180/2013
• Status: Completed
• Phase: N/A
• Start date: April 2013
• Est. completion date: June 2018

Study information

• Verified date: March 2021
• Source: Turku University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: June 2018
• Est. primary completion date: June 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Native Finnish speaker

2. Age > 18 years

3. Western Caucasian origin

Exclusion Criteria:

1. Age < 18 or > 65

2. History or current mental disorder

3. BMI > 27 kg/m2

4. Use of drugs that influence the central nervous system, including nicotine

5. Poor compliance

6. Any chronic medical defect or injury which hinder or interfere everyday life

7. Eating disorder

8. Current or past excessive use of alcohol or substance abuse

9. Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv

10. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results

11. Presence of any ferromagnetic objects that would make MR imaging contraindicated

Related Conditions & MeSH terms

• Physical Exercise Behavior (Liking/Aversion)

Intervention

Behavioral:
• Exercise

Locations

Country	Name	City	State
Finland	Turku PET Centre	Turku

Sponsors (5)

Lead Sponsor	Collaborator
Turku University Hospital	Academy of Finland, Juho Vainio Foundation, Novo Nordisk A/S, University of Turku

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Binding of [11C]carfentanil in brain confirmed by positron emission tomography	Change in binding of [11C]carfentanil in baseline and 20 min after physical exercise completion	Baseline and 20 min after physical exercise completion