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NCT02578342 Clinical Trial

Brain Activity in Adults With ADHD During Neuropsychological Tasks

Attention Deficit Hyperactivity Disorder (ADHD) Clinical Trial

Official title:
Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02578342
Other study ID # 1410.000.055
Secondary ID
Status Completed
Phase
First received
Last updated
Start date August 2015
Est. completion date November 2020

Study information
Verified date April 2022
Source Kantonsspital Aarau
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.

Description:

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood. The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested. Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.

Recruitment information / eligibility
Status Completed
Enrollment 45
Est. completion date November 2020
Est. primary completion date May 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 55 Years
Eligibility Inclusion Criteria: - Participant is between 20-55 years old - Participant is not pregnant Exclusion Criteria: - Participant is not able to consent him/herself - Suspected or proven pregnancy - Nursing - Neurological diseases that could interfere with a diagnosis of ADHD - Psychiatric comorbidity under treatment - Previous history of psychiatric medication - Substance abuse - Intelligence quotient<75 - Claustrophobia - Electrical simulator nerve or bone - Implanted medication infusion pump - Cerebral aneurysm clips - Unstable medical condition

Study Design

Related Conditions & MeSH terms

  • Attention Deficit Disorder with Hyperactivity
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Hyperkinesis

Intervention

Device:
• MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency

Locations
Country Name City State
Switzerland Kantonsspital Aarau Aarau Aargau

Sponsors (1)
Lead Sponsor Collaborator
Kantonsspital Aarau

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Changes in blood oxygenation level dependency (BOLD) The study consist solely of one MRI examination performed within 2 hours. 2 hours
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