Stiffness of Shoulder, Not Elsewhere Classified Clinical Trial
Official title:
Pathomechanism of MicroRNA-29 in Shoulder Stiffness
The team integrates experimental analyses of clinical and basic medicine and transgenic mice models. miR-29a acts a potent protective factor against excessive fibrosis in myofibroblasts of subacromial bursa tissue. Gain of miR-29a stabilizes tendon and synovial tissue homeostasis that alleviates tissue stiffness and maintains function.
Aims of first: The team will evaluate the associations among the mR-29a, miR-29b, miR-29c
expression in subacromial bursa and subacromial fluid, incidence of shoulder stiffness,
Constant scores, and VAS.
Aims of second: The team will isolate primary myofibroblast from subacromial bursa tissue as
in vitro models and investigate the molecular events in the IL-1β modulation of miR-29a
expression and the molecular mechanism underlying miR-29a inhibition of fibrotic matrix
accumulation and apoptotic reactions in myofibroblast cultures.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05540301 -
Sleeper's and Adduction Stretch to Increase Shoulder ROM
|
N/A | |
| Recruiting |
NCT02450864 -
The Biological Effect of ESWT and the Role of Proinflammatory Cytokines and Cannabinoid Receptor in Shoulder Stiffness
|
N/A |